Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2–host interacti...
Am J Hum Genet 110(2):215–227 Hromadkova L, Bezdekova D, Pala J, Schedin-Weiss S, Tjernberg LO, Hoschl C, Ovsepian SV (2020) Brain-derived neurotrophic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons. Biochim Biophys ...
TAMs were thought to closely resemble the M2 pheno- type; however, recent findings suggested that this binary polarization model was oversimplified and a spectrum model of TAM phenotypes has been proposed instead [52]. TAM is highly plastic within TME, where they display different characteristics ...
Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution of AMI patients. We hypothesized that transcriptional RN
Differences in the expression patterns of genes have been used to measure the effects of non-stress or stress conditions in poultry species. However, the list of genes identified can be extensive and they might be related to several biological systems. T
Because of its widespread use, permethrin contaminates the environment in several ways and has toxic effects on non-target organisms. Permethrin exposure disrupts the balance of the antioxidant system in non-target organisms and causes oxidative damage to DNA, lipids, and proteins (Weidinger and ...
Schaale K. et al.15 further found that Wnt6 expressed in granulomatous lesions participated in macrophage dif- ferentiation and proliferation by driving macrophage polarization toward an M2-like phenotype. The specific molecular mechanism of the WNT pathway in the progression of MTB has garnered ...
The polygenic nature of complex diseases offers potential opportunities to utilize network-based approaches that leverage the comprehensive set of protein-protein interactions (the human interactome) to identify new genes of interest and relevant biologi
(Fig.1g). Many targets of M1- and M2-activating compounds belong to the families of histone deacetylases and vascular endothelial growth factor (VEGF) receptors, respectively (Supplementary Fig.2). Some known regulators of macrophage polarization, such as STAT3, FYN, MAP2K1, and CDKs6, were ...
in the northern Al-Kabeer River basin of the northern Province of Latakia in Syria in 2012–2014 were mainly caused by the war and the firing of shells and bombs in the area. These findings support our conclusion that shelling and bombing can be major causes of forest fires and ...