Genetic mapping studies have identified thousands of associations between common variants and hundreds of human traits. Translating these associations into mechanisms is complicated by two factors: they fall into gene regulatory regions; and they are rar
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2–host interacti...
Schaale K. et al.15 further found that Wnt6 expressed in granulomatous lesions participated in macrophage dif- ferentiation and proliferation by driving macrophage polarization toward an M2-like phenotype. The specific molecular mechanism of the WNT pathway in the progression of MTB has garnered ...
Bayesian network and community analysis of a set of genes. 19 genes showing differences in expression pattern were initially included at the time of learning the structure of the network in addition to the stressful condition; however, only 16 out of those 19 were linked in a network structure....
Toxoplasma gondiiis an obligate intracellular parasite that causes disease in immunocompromised individuals, such as HIV/AIDS patients, and when contracted congenitally1. It causes lifelong infections by converting from rapidly dividing tachyzoite stages into encysted slow-growing bradyzoites, which mainly...
MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function Fang Ni1,2*, Chuang Guo1*, Rui Sun1, Binqing Fu1,3, Yue Yang2, Lele Wu2, Sitong Ren2, Zhigang Tian1,3 & Haiming Wei1 1Institute of Immunology and the ...
Because of their critical function in maintaining tissue homeostasis and repair, dysregulation of macrophage polarization has been implicated in contributing to many human diseases including cancer, fibrosis, obesity, diabetes, and infectious, cardiovascular, inflammatory, and neurodegenerative diseases7,8,9....
The polygenic nature of complex diseases offers potential opportunities to utilize network-based approaches that leverage the comprehensive set of protein-protein interactions (the human interactome) to identify new genes of interest and relevant biologi
These findings support our conclusion that shelling and bombing can be major causes of forest fires and deforestation. In addition to these causes, charcoal production by locals in forested areas could be another contributor to forest fires. This process involves “charring” or partially burning ...