The term “Cervical cancer” is characterized by an abrupt and unusual growth of cells in the cervical lining. The cause of this disease is the human papillomavirus (HPV) attack on the body and the medium of transmission is sexual intercourse. This abnormal cell growth is called dysplasia or ...
The N-terminal 125 amino acids of theDrosophila P element transposase are necessary and sufficient for the nuclear localisation of a hybridlacZ gene product in most cell types of theDrosophila embryo. A P-lacZ enhancer-trap element lacking these residues is of use in visualizing the shapes of ...
pulmonary carcinoids are low-grade typical and intermediate-grade atypical well-differentiated lung neuroendocrine tumours (LNETs) that belong to the group of lung neuroendocrine neoplasms (LNENs), which also includes the high-grade and poorly differentiated small-cell lung cancer (SCLC) and ...
To complement our CRISPR-based gene editing studies, we also performed CRISPR-based gene activation screens to define genes associated with PROTAC resistance. Pools of MM.1S cells expressing a dCas9-VP64 fusion were transduced with the Calabrese genome-scale library of sgRNAs for P65-HSF (heat...
and Ratcliffe (2005), “a hotspot represents an area of high crime concentration, relative to the distribution of crime across the whole region of interest” and present accurate and specific point data (Chainey and Ratcliffe2005; Kulyk and Sossa2018). There is no universal standard to define ...
Cardiac arrest is a common and devastating emergency of both the heart and brain. More than 380,000 patients suffer out-of-hospital cardiac arrest annually in the USA. Induced cooling of comatose patients markedly improved neurological and functional out
In particular, we found a DEAD-box RNA helicase, DDX3X, binds the GGGGCC repeat RNA and represses the RAN translation from all three reading frames. The requirement of helicase activity suggests DDX3X unwinds or alters the repeat RNA structure, which is essential for RAN translation initiation....
We used MITOMASTER and PhyloTree, build 5 Van Oven et al22 to define the mtDNA European Journal of Human Genetics Mitochondrial cardiomyopathies MV Zaragoza et al 202 Table 1 Clinical features and sequencing results for 29 Italian patients with mitochondrial cardiomyopathy (1–21) or suspected ...
by expressing anti-inflammatory cytokines, such as IL-10, TGFβ, and arginase, M2 macrophages mediate tissue repair, but can also mediate fibrosis if dysregulated. While M1 and M2 serves to define the opposite activating states of macrophages in simplistic manner, most macrophages exhibit multidimens...
Ajay Kumar Saxena & Rajendra Prasad† The ABC transporter Cdr1 protein (Cdr1p) of Candida albicans, which plays a major role in antifungal resistance, has two transmembrane domains (TMDs) and two nucleotide binding domains (NBDs) that are interconnected by extracellular (ECLs) and intrace...