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for neurodevelopment such as LHX2, HES5, SIX3 (homeobox protein SIX3; crucial for forebrain development; mutations: holoprosencephaly) and ARX (aristaless-related homeobox; mutations are associated with neurological and neurodevelopmental disorders such as lissencephaly, epilepsy, mental retardation) (...
Under the conditions utilized, where [label] < [MHC] and IC50 ≥ [MHC], the measured IC50 values are reasonable approximations of the true Kd values60, 61. Each competitor peptide was tested at six concentrations covering a 100,000-fold dose range. As a positive control, the ...