The need for secondary pharmacology screening presents unique challenges for novel therapeutic modalities. The current approach of in vitro secondary pharmacology screening does not detect protein level changes. Consequentially, proteomics is already being used to assess these therapeutics10, despite that ...
Mendelian randomisation for mediation analysis: current methods and challenges for implementation. Eur J Epidemiol. 2021;36:465–78. Article PubMed PubMed Central Google Scholar Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: ...
HIV prevention in the UK remains problematic; effectiveness of current prevention efforts appears limited; novel and innovative, evidence-based approaches are needed in HIV prevention. HIV prevention remains one of the great challenges for sexual health in the UK[32]. This study offers a method for...
Challenges Before applying facial recognition to Roman imperial portrait recognition, we have to address several issues. First, when compared to real human faces, the portraits of Roman emperors lack important features such as texture and colour. These features are very likely used by existing face ...
Although restraints of human activities can effectively reduce the overall incidence of COVID-19 [40], the behaviors described in Factor 3 have been a trifle going against morals. Thus, regardless of their employment and educational backgrounds, people may have the ability to identify them. However...
We overcome the persistent challenges of identifying alterations or driver mutations in coding regions related to tumorigenesis through a novel approach combining multi-omics data with clinical information to reveal the molecular mechanisms underlying non-CAGAs LUAD, stratify patients to improve patient pro...
Overall, despite these challenges the identified novel loci and genetic variants highlighted novel potential targets for T2D etiology in Qatar, which may be explored further in functional studies to determine the molecular pathways affected by them....
Carbon dot-based fluorescent sensors for pharmaceutical detection: Current innovations, challenges, and future prospects Heliyon, Volume 10, Issue 24, 2024, Article e41020 Sandesh R. Lodha,…, Shashikant P. Patole View PDFShow 3 more articles ...
The transition from linear production towards a circular agro-food system is an important step towards increasing Europe’s sustainability. This requires re-designing the food production systems, which inevitably comes with challenges as regards controll
R. Targeting pan-essential genes in cancer: challenges and opportunities. Cancer Cell 39, 466–479 (2021). Article CAS PubMed PubMed Central Google Scholar Sondka, Z. et al. The COSMIC cancer gene census: describing genetic dysfunction across all human cancers. Nat. Rev. Cancer 18, 696...