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The article reports on the approval of the xTAG Respiratory Viral Panel by the Food & Drug Administration (FDA) in the U.S. in 2008. It mentions that it is the first test that identifies 12 specific respiratory viruses from a single sample, including influenza A subtypes H1 and H3. In ...
Areas shaded in color in each panel indicate 95% error bands for lines of the same color. Extended Data Fig. 2 Kaplan-Meier survival curves by PhenoAge and PCAge categories for male and females. We compared PhenoAge’s and PCAge’s ability to stratify the test cohort by either first ...
Significance in survival was determined using the log rank (Mantel-Cox) test. d Growth rate inhibition curves of parental SMB cells and derivatives of SMB21 cells depicting the efficacy and potency of LDE-225 (left panel), GDC-0449 (middle panel) and 5-AzaC (right panel) for 72 h (n...
(RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide ...
pH 4.0) subcutaneously at 2 days of age. Mice were fed a high-fat diet (TestDiet 58R3, 1810835) from 30 days of age. All STZ–HFD-treated livers showed pale yellow colour at 6 weeks, mild swelling at 8 weeks, granular surface at 12 weeks and tumour protrusion at 20 weeks of ...
2.2. Antiviral drug screening Vero cells were grown as a monolayer in 24-well plates, the cells were treated with 10 μM compound or 0.1% DMSO for 4 h. The cells were washed with PBS, then infected with DR13-GFP (0.1 MOI). At 12, 24 and 36 h post infection (hpi), CPE were ob...
Schematic representation of the docking interactions between critical genes and the most significant respiratory system drugs. Each panel highlights the binding interface between a critical gene and its corresponding drug Full size image Phenome-wide mendelian randomization (PheW-MR) ...
Conflict of Interest Disclosures: Dr Doran reported receiving payment from Abt Associates for serving on a technical expert panel for work related to homelessness and substance use and royalties from Springer for the textbook Social Emergency Medicine: Principles and Practice outside the submitted work...
To systematically define molecular features in human tumor cells that determine their degree of sensitivity to human allogeneic natural killer (NK) cells, we quantified the NK cell responsiveness of hundreds of molecularly annotated ‘DNA-barcoded’ soli