Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. To investigate the function of
because they exhibited the highest accuracy among the four machine learning methods (Supplementary Fig.6). To address overfitting, a ridge regularization term that penalizes the L2-norm of feature weights was included in the models. No LASSO regularization was used, as it induces sparsity and exclu...
Human pathogens are widespread in the environment, and examination of pathogen-enriched environments in a rapid and high-throughput fashion is important fo
of community dynamics including dominant strain switches and rare strains. The simulated datasets address performance in the context of different within-population diversities, different numbers of strains, the interference from other species within the same community, as well as the scalability of the ...
To address this we compared the enrichment of known pathogen interactors, which we consider to be interesting targets, in the most highly differentially regulated proteins from each dataset (see Figure 1) and the proteins with highest betweenness in the network derived from each dataset. This ...
Tef (Eragrostis tef), an indigenous cereal critical to food security in the Horn of Africa, is rich in minerals and protein, resistant to many biotic and abiotic stresses and safe for diabetics as well as sufferers of immune reactions to wheat gluten. We
To address the possibility that coilin interacts directly with RNA and to globally identify target transcripts, we used CLIP, a 0 Å UV crosslinking method that includes immunopurification and deep sequencing of bound RNAs (Ankö and Neugebauer, 2012, König et al., 2011). CLIP has ...
(ERG) K+current is largely responsible for termination of the depolarized plateau. The mechanisms and slow processes identified herein may contribute to bursting as well as entry into and recovery from the depolarization block to different degrees in different subpopulations of dopamine neurons in vivo...
Correspondence: Professor SA Kushner, Department of Psychiatry, Erasmus University Medical Center, Dr Molewaterplein 50, Ee-1442, Rotterdam, 3015 GE, The Netherlands. E-mail: s.kushner@erasmusmc.nl 6Present address: Aix Marseille Université UMR 901, Marseille, France. 7Present address: Institut ...
To address the current gap in Sjögren’s genetics, we performed the largest GWAS to date in Sjögren’s of European ancestry, resulting in the identification of ten novel GWS associations (Fig. 1a). Using genotyped SNPs, we also assessed the genetic correlation with related autoimmune ...