Fig. 3: The TMX1–DIESL enzymatic complex drives alternative triglyceride synthesis. a, Immunoblot analysis of TMX1 and haemagglutinin (HA)-tagged DIESL (3×HA–DIESL) in HAP1 cells lacking endogenous DIESL (and TMX1), with or without crosslinking by 1% paraformaldehyde (PFA). Red arrowhead...
triglyceride-rich lipoproteins have been suggested to trigger endothelial dysfunction28 and arthero- thrombosis,29 and they also play an important role in thrombin formation and may induce platelet aggregation, which can contribute to coagulopathy, another characteristic of PE.30 An alternative explanation...
Plasma triglyceride levels are markers of diabetes progression and incident diabetes Among the 162 lipids investigated, the levels of nine reached significance in the base model (Fig. 2). Among these eight lipids were a risk factor for early insulin requirement, and these were all triglycerides (...
4). The normalised abundance values of four of the 70 compound ions (2 wax esters, 1 diglyceride and 1 triglyceride) were significantly higher (p < 0.05) in males than in females (Fig. 5). Fig. 4 Commonalities and differences in the number of compound ions detected in positive ...
Plasma triglyceride levels are markers of diabetes progression and incident diabetes Among the 162 lipids investigated, the levels of nine reached significance in the base model (Fig. 2). Among these eight lipids were a risk factor for early insulin requirement, and these were all triglycerides (...
Numerous studies have shown LAP to be an effective predictor of cardiovascular metabolic conditions, such as hypertension, stroke, diabetes, and psoriasis [24,25,26,27,28]. LAP was also a better predictor of MetS than the triglyceride-glucose (Tyg) index, BMI, WC, WHtR, waist-to-hip ratio...
Thus, using two independent techniques, proteolytic digestion and binding of monoclonal antibodies, we have demonstrated an alternative conformation of apoB-100 in the vicinity of residue 1076, which reflects the content of triglycerides in the LDL particle....
1 HSL contains an α/β-hydrolase fold2 and a catalytic triad of serine, aspartic acid, and histidine,3 which are essential for catalysis.4 The highest expression of HSL is observed in adipose tissues (ATs) where it catalyzes lipolysis of stored triglyceride (TG); one TG molecule is ...
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in three
The autophagic process is a highly conserved system of degrading nonessential components within cells. The autophagy process is activated during times of metabolic stress for the purpose of providing alternative energy sources, including autophagosome formation, nucleation, double-membrane growth and closure...