ICVB-1042 produced more viral genomes via replication than comparators, particularly at high MOIs. ICVB-1042 showed significant tumor growth inhibition and increased overall survival compared to vehicle-treated animals. ICVB-1042 infection, replication, and cytolysis were evident across all diverse ...
ICVB-1042, an oncolytic adenovirus containing modifications to enhance replication, lysis, and viral spreading in tumor cells, demonstrated safety and potency in multiple tumor cell lines and mouse models of solid tumors.doi:10.1038/s42003-024-06839-6Kato, Yu...
ICVB-1042 has been further engineered with a chimeric fiber to enhance its tumor tropism and a modified capsid hexon protein to allow intravenous (IV) delivery. This combination of rationally designed modifications enables ICVB-1042 to be used for the treatment of a wide range of solid tumor ...
We engineered ICVB-1042, a potent, selective, and systemically available OV, with an Ad5/Ad34 chimeric fiber to enable viral entry via CD46 instead of CAR proteins. Here, we demonstrate the cell entry requirements for ICVB-1042 compared to ICVB-421, an Ad5-derived virus with wild-type...
ICVB-1042 showed significant decreases in tumor volume and significant increases in TTP between treated and control animals at both doses. ICVB-940 showed significant decreases in tumor volume but nonsignificant increases in TTP at the high dose; no significant differences in tumor volume or TTP ...