The 11p15 region harbors the IGF2/H19 imprinted domain, implicated in fetal and postnatal growth. Silver-Russell syndrome (SRS) is characterized by fetal and postnatal growth failure, and is caused principally by hypomethylation of the 11p15 imprinting control region 1 (ICR1). However, the ...
美國設計團隊BANGIA AGOSTINHO作品:Fort Greene Townhouse,這是一幢位於紐約布鲁克林的聯排别墅,始建於 1861 年,位於歷史悠久的格林堡社區。業主夫婦為這個住宅帶來了不同的背景:妻子是一名室內設計顧問,擁有時尚和品牌方面的經驗;丈夫來自威爾士,從事企業投资工作。他們的愿景從一開始就很明確:他們希望自己的家既能兼...
Microduplication of the ICR2 domain at chromosome 11p15 and familial Silver-Russell syndrome. Am J Med Genet A 2011;155A:2479-83.Bonaldi A, Mazzeu JF, Costa SS, Honjo RS, Bertola DR, Albano LM, Furquim IM, Kim CA, Vianna-Morgante AM. Microduplication of the ICR2 domain at chromosome...
Background The structural organisation of the human IGF2/ICR1/H19 11p15 domain is very complex, and the mechanisms underlying its regulation are poorly understood. The Imprinted Center Region 1 (ICR1) contains seven binding sites for the zinc-finger protein CTCF (CBS: CTCF Binding Sites); ...
Complex tissue-specific epigenotypes in Russell-Silver Syndrome associated with 11p15 ICR1 hypomethylation. Hum Mutat 2014;35:1211-20.Azzi S, Blaise A, Steunou V, Harbison MD, Salem J, Brioude F, et al. Complex tissue-specific epigenotypes in Russell-Silver syndrome associated with 11p15 ICR...
Azzi S, Steunou V, Tost J, Rossignol S, Thibaud N, Das Neves C, et al. Exhaustive methylation analysis revealed uneven profiles of methylation at IGF2/ICR1/H19 11p15 loci in Russell Silver syndrome. J Med Genet. 2015;52(1):53–60. : 10.1136/jmedgenet-2014-102732 ....