ApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling. In the adult brain, Reelin potentiates excitatory synapses and thereby protects against amy...
Monotherapy methods for cancer therapy are likely to fail because of inter- and intra-patient heterogeneity of cancer, the diverse nature of cancer cells genomes, and the dynamic condition of the tumor milieu. A synergy between OVs and CAR T-cells seems to be the ideal way to organize a mul...