Sibony M, Alifano M, Dondi E, Bercovici N, Trautmann A, Kaiser AD, Donnadieu E. CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1. Cancer Immunol Res. 2021 Dec;9(12):1425-1438
11 reagents referenced in ICAM-1-dependent homotypic aggregates regulate CD8 T cell effector function and differentiation during T cell activation.
Developmental Cell05影响因子 12.2706出版时间 2022年2月 文章简介 近来研究表明,肿瘤外泌体表面携带的PD-L1在肿瘤免疫逃逸及肿瘤治疗耐受中发挥着重要作用。肿瘤外泌体((TEVs) PD-L1可与细胞毒性CD8 T细胞表面的PD-1结合,抑制CD8 T细...
CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1. Cancer Immunol Res. 2021 Dec;9(12):1425-1438. doi: 10.1158/2326-6066.CIR-20-0837. Epub 2021 Oct 22. PMID: 34686489. 2.Salmon H, Franciszkiewicz K, Damotte D, Dieu-Nosjean MC, Validire ...
Alifano M, Dondi E, Bercovici N, Trautmann A, Kaiser AD, Donnadieu E. CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1. Cancer Immunol Res. 2021 Dec;9(12):1425-1438. doi: 10.1158/2326-6066.CIR-20-0837. Epub 2021 Oct 22. PMID: 34686489....
Conclusion These LFA-1-targeted EVs were able to interact with T cells as their recipient cells. They can be utilized as an ideal delivery system to transfer various biomolecules to T cells, facilitating immunotherapies or other cell-based treatments....
Developmental Cell 05影响因子 12.27 06出版时间 2022年2月 文章简介 近来研究表明,肿瘤外泌体表面携带的PD-L1在肿瘤免疫逃逸及肿瘤治疗耐受中发挥着重要作用。肿瘤外泌体((TEVs) PD-L1可与细胞毒性CD8 T细胞表面的PD-1结合,抑制CD8 T细胞的增殖及活化,是肿瘤外泌体抑制宿主免疫的重要机制。然而肿瘤外泌体与CD...
受体的其他黏附分子相互结合, 如LFA-1/ICAM-1、LFA-2/ICAM-2、Mac-1/ICAM-1、VLA-4/VCAM-1等. 这样导致白细胞与内皮细胞的稳定黏附, 致使特定的细胞亚群定位于此处. 最后, 由免疫球蛋白超家族成员血小板内皮细胞黏附分子-1(platelet endothelial cell adhesion molecule-1, PECAM-1)介导白细胞穿过内皮向...
the development of EAE. In this study, we show using a newly developed transgenic mouse (CD2-Icam1(D4del) /Icam1(null) ) that T-cell-specific expression of a single ICAM-1 isoform composed of Ig domains 1, 2, 3, and 5 can mediate the initiation and progression of EAE. Our results...
Wound healing and inflammation are both significantly reduced in mice that lack γδ T cells. Here, the role of epithelial intercellular adhesion molecule-1 (ICAM-1) in γδ T cell migration in corneal wound healing was assessed. Wild-type mice had an approximate fivefold increase in ...