Full size image In situ assessment of tau tangle conformation in DS Because older DS brains feature AD neuropathological changes, we postulated that tau conformers should resemble those found in typical late-onset sAD brain samples. Indeed, others have shown that NFTs are positive for three-repe...
Sex is an important factor that contributes to the clinical and biological heterogeneities in Alzheimer’s disease (AD), but the regulatory mechanisms underlying sex disparity in AD are still not well understood. DNA methylation is an important epigeneti
Full size image CD68 is a commonly used marker for macrophages, immunofluorescence staining revealed that ICA69 and CD68 were colocalized, and the expression of ICA69 and CD68 were significantly increased in the LPS-induced failing hearts (Fig. 1E). As far as we know, the clinical manifestatio...
Download: Download full-size image Figura 3. Resultados ecocardiográficos após três meses. a) Ecocardiografia transtorácica quatro câmaras prévia à intervenção. b) Doppler contínuo mostrando gradiente subaórtico prévio à intervenção. c) Ecocardiografia transtorácica quatro c...
Full size image Clusters 1 (30 genes) and 4 (25 genes) showed a pattern of linear increase and decrease in expression from Braak LB stage 0 to stage 6, respectively. The top hit gene of the up-regulated cluster (1) was SNX7 (Supplementary Fig. 5a), whereas the top hit of the down...
Download: Download full-size image Esquema general del estudio. Ensayo clínico controlado, abierto y aleatorizado en el que se estudia la eficacia de una revista educacional en la disminución del incumplimiento farmacológico de la hipertensión arterial. Resultados Se seleccionaron 450 pacientes. ...
Full size image Potential protective alleles against APOEε4 enrich extracellular matrix components To determine the molecular mechanisms enriched in the protective alleles that we identified, gene ontology review was performed with term analyses for biological processes, cellular compartments, and molecular ...
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Full size image Other morphometric alterations such as the fourth ventricle, the volume corresponding to the pericerebellar CSF spaces, and grey and white matter content in the cerebellum were evaluated by MRI. Similarly to what has been reported in humans MJD patients [29, 30], the volume of...
Full size image The difficulty of interpreting microglial morphology and phenotype in human brain Histopathological studies of microglia can be a valuable diagnostic aid to neuropathologists, a fact that was already recognized many decades ago by del Rio-Hortega, who wrote: “It is sufficient to fi...