Group 5 served as standard, administered with Atorvastatin (10 mg/kg) along with HCD and Group and Group 5 were administered with methanolic extract of polyherbal preparation (300 mg/kg and 600 mg/kg) along with HCD. Methanolic extract of polyherbal preparation reduced the raised serum level ...
Keywords: atorvastatin;bone metabolism;bone mineral density;hypercholesterolemia 骨质疏松症(osteoporosis,OP)是骨强度下降导致 骨折危险性升高的一种骨骼疾病。 目前全球 OP 患者 已经超过2 亿人,我国随着人口向老龄化发展,OP 发 病率更是呈上升趋势。 他汀类药物是目前临床治疗高 胆固醇血症的首选药,其具有降脂外...
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Hypercholesterolemia study: LY518674 (10 mug or 50 microg) decreased LDL-C by 21.4 to 26.0 mg/dL (13.2%-15.8%) and triglycerides approximately 37% for both doses, and increased HDL-C by 6.3 to 6.7 mg/dL (12.5%-15.0%). When added to atorvastatin, LY518674 changed HDL-C by -0.7 ...
Pravastatin or ator- vastatin were administered for 3 weeks at doses of 40 and 20 mg/kg/day, respectively. Formation of H2S from cysteine in PAT homogenates in vitro was 64% higher in atorvastatin-treated rats, whereas in pravastatin-treated animals did not differ from con- trol. H2S ...
negative control group (G2) was fed high cholesterol and fat diet (HCFD), positive control group (G3) was fed HCFD and treated with atorvastatin (20mg/kg), a fourth, fifth and sixth groups (G4, G5, and G6) were fed HCFD and treated with 10, 30 and 100mg/Kg of BMME, respec...