The invention relates to a preparation method of ibuprofen arginine salt. The method comprises the following steps of: reacting ibuprofen with arginine in water; and after reacting, drying a reaction liquid. In the preparation method provided by the invention, an arginine solid and an ibuprofen ...
Schwartz JI, Vandormael K, Malice MP, Kalyani RN, Lasseter KC, Holmes GB, Gertz BJ, Gottesdiener KM, Laurenzi M, Redfern K-J, Brune K (2002) Comparison of rofecoxib, celecoxib, and naproxen on renal function in elderly subjects receiving normal-salt diet. Clin Pharmacol Ther 72:50–61...
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N-a-Methyl-DL-arginine [4,5-3H] DL-NMMA C7H16N4O2 N-Methyl-[3H]-L-aspartic acid NMLA HO2CCH2CH(NHCH3)CO2H 2-Methyl-4-chlorophenoxyacetic acid [ring-14C(U)] MCPA ClC6H3(CH3)OCH2CO2H N-Methyldiethanolamine [methyl-14C] (HOCH2CH2)2NCH3 ...
Scheme 3.Structures of therapeutic agents existing under salt form with arginine. Sign in to download full-size image Fig. 7.Selected molecular structures for pharmaceutical salts including arginine amino acid (MC and SC interactions for selected amino acid highlighted in black and gray respectively)...
Ibuprofen is a chiral nonsteroidal anti-inflammatory drug (NSAID) of the 2 arylpropionic acid (2-APA) class. A common structural feature of 2-APA NSAIDs is
Ibuprofen as a carboxylic acid can form salts with bases, such as basic amino acids, examples of which are lysine and arginine. The low solubility of the acid form of ibuprofen is overcome by the use of the lysinate salt of ibuprofen. U.S. Patent 4,279,926 describes the use of the ly...
United Kingdom patent publication GB 2,219,585 (Reckitt & Colman) discloses a complex of β-cyclodextrin with the sodium, potassium, ammonium, magnesium, calcium, arginine, glycine or lysine salt of ibuprofen, having a molar ratio of ibuprofen to β-cyclodextrin in the range 1:0.2 to 1:0.7...
The invention provides a method for preparing an ibuprofen arginine salt with ultrahigh purity. The method is characterized in that during an ibuprofen arginine salt preparing process, the molar ratio of ibuprofen to an arginin raw material is 1:1; only water serves as a solvent during a salt...
The preparation method of the ibuprofen arginine salt comprises the following steps of: firstly adding arginine and ethanol for heating and stirring; and then adding ibuprofen to obtain the ibuprofen arginine salt through crystallization, temperature reduction, standing, filtering and drying. The ...