In addition, IRSp53 has been implicated in diverse psychiatric disorders, including autism spectrum disorders, schizophrenia, and attention deficit/hyperactivity disorder. Mice lacking IRSp53 display enhanced NMDA (N-methyl-d-aspartate) receptor function accompanied by social and cognitive deficits, which ...
4B). In addition, THP-1 cells transfected with the WT pc-IAP2Pr were treated with CAPE, a broad spectrum NF-κB inhibitor, for 2 h prior to stimulation with either LPS or TNF-α followed by determination of c-IAP2 expression by luciferase activity. Treatment of cells with CAPE inhibited ...