≥?three additional copies of RUNX1 on a single abnormal iAMP21‐chromosome. We sought to evaluate the performance of the RUNX1 probe in the identification of iAMP21‐ALL. This study was a retrospective evaluation of iAMP21‐ALL in the Mayo Clinic and Children's Oncology Group cohorts. Of ...
Intrachromosomal amplification of chromosome 21 (iAMP21) identifies a high-risk subtype of acute lymphoblastic leukaemia (ALL), requiring intensive treatment to reduce their relapse risk. Improved understanding of the genomic landscape of iAMP21-ALL will
581 Patients with iAMP21 (intrachromosomal amplification of chromosome 21) represent a distinct cytogenetic subgroup of childhood B cell precursor ALL (BCP-ALL; incidence 2%) with a poor prognosis on standard therapy (29% EFS at 5 years). From cytogenetic studies the amplification of chromosome 21...
et al. The role of the RAS pathway in iAMP21-ALL. Leukemia 30, 1824-1831 (2016).Ryan SL, Matheson E, Grossmann V, et al. The role of the RAS pathway in iAMP21- ALL. Leukemia 2016;30:1824-31.Ryan SL, Matheson E, Grossmann V, et al. The role of the RAS pathway in iAMP21-...
Blood Spotlight on iAMP21 acute lymphoblasticleukemia (ALL),a high-risk pediatric disease [ J ]. Blood,2015,125(9): 1383-1386. DOI: 10.1182/bIood-2014-08-569228.Harrison, Christine J.. Blood Spotlight on iAMP21 acute lymphoblastic leukemia (ALL), a high-risk pediatric disease[J].Blood:...
656 Chromosomal abnormalities present in the bone marrow cells of children with acute lymphoblastic leukaemia (ALL) are used to assist diagnosis and define risk groups that guide therapy. One such primary genetic aberration is intrachromosomal amplification of chromosome 21 (iAMP21) which is defined ...
In the same way as we described previously for carriers of the constitutional Robertsonian translocation, rob(15;21)c, it appears that r(21)c chromosomes are also predisposed to iAMP21-ALL, throughClaire SchwabEigil Kjeldsen MD DMScNyla A. Heerema PhD...
Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21) Blood. 2007; 109 :2327–2330.Moorman AV, Richards SM, Robinson HM, et al. Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of ...
PS921 INACTIVATION OF SH2B3 THROUGH CN-LOH 12Q IS UNIQUELY ASSOCIATED WITH B-CELL PRECURSOR ALL WITH IAMP21 OR OTHER CHROMOSOME 21 GAINdoi:10.1097/01.HS9.0000561960.84253.74Sinclair, P.Ryan, S.Bashton, M.Hollern, S.Hanna, R.Case, M....
PS921 INACTIVATION OF SH2B3 THROUGH CN-LOH 12Q IS UNIQUELY ASSOCIATED WITH B-CELL PRECURSOR ALL WITH IAMP21 OR OTHER CHROMOSOME 21 GAINdoi:10.1097/01.HS9.0000561960.84253.74Sinclair, P.Ryan, S.Bashton, M.Hollern, S.Hanna, R.Case, M....