Type 1 diabetes mellitus (T1DM) is an autoimmune disorder accompanied by activation of auto-reactive B cells, autoantibody production, and consequently insulin-producing beta cell destruction. Some evidences support the value of autoantibodies such as anti-islet cell antigen (IA-2) auto-antibody in ...
IA-2/PTPRN was found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker. 实验方案 Product Specific Protocols WB protocol for IA-2/PTPRN antibody 10584-1-AP Download protocol IHC ...
Diabetes Mellitus, Type 1Transplantation, HomologousAntibodiesHistocompatibility Antigens Class IIIslets of Langerhans TransplantationAntibody SpecificityAutoimmunityAdultThe transmission of infectious and neoplastic diseases is a potential risk of tissue allografting. In this study, we analyzed the occurrence of ...
We evaluated a insulinoma-associated protein (IA-2) antibody assay kit using 125I-labelled recombinant IA-2. IA-2 antibodies were present in patients with early-onset type 1 diabetes mellitus (DM) at frequencies of 74%, 67%, 57%, and 50% for respective periods <1 year, l<years<2, 2...
胰岛β细胞自身抗体IA-2Ab的ELISA方法建立——附110例正常人测定值
We evaluated two kinds of ELISA: ELISA with biotin-IA-2 directly captured on streptavidine-coated plates (solid phase) and ELISA with antigen-antibody preincubation in solution in which serum samples were reacted first with biotin-IA-2 and the mixture was transferred to streptavidine-coated ...
第一部分lA-2 S A在1型糖尿病患者中的分布规律及GADA、 IA-2A、IA_213A联合检测对1型糖尿病的诊断价值 目的:1.了解IA-2BA在中国1型糖尿病(T1DM)患者中的阳性 检出率;2.探讨IA-2flA在T1DM患者中的分布规律;3.分析GADA、 IA.2A、IA-2BA联合检测对T1DM的诊断价值。
Idiabetes andthecombineddetectionofIAC IA2-AbandGAD-Abismoreaccurate andithasimportantsignificancefor earlyandaccurateclassificationofclinicaldiabetes. [Keywords]Glutamicaciddecarboxylaseantibody;Tyrosinephosphataseantibody;Isletcellantibody;Typeofdiabetes 17 ...
OBJECTIVE: Autoantibodies to IA-2beta (IA-2betaA) are important risk markers of type 1 diabetes. We report the first Diabetes Antibody Standardization Program (DASP) evaluation of IA-2betaA assays. RESEARCH DESIGN AND METHODS: Thirteen laboratories from nine countries received coded sera from 50...
diabetes antibody GADA,ICA,IAA and IA 2A.[Result] The relevance ratios of 4 items of antibody in T1DM are respectively65.33%,38.00%,24.67%,10.67%;17.27%,13.69%,12.50%,5.95% in T2DM;0.00%,1.00%,0.00%,2.00% in normal control group.There’s marked difference between T1DM,T2DM and normal ...