suggest a relationship between antibiotic use in preterm infants, the microbial composition of the gastrointestinal tract, and the subsequent development of NEC [21,47]. Additional studies suggest that the acid–base environment of the gastrointestinal tract may also play a significant role in the ...
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In vitro studies demonstrated a plazomicin post-antibiotic effect ranging from 0.2 to 2.6 hours at 2× MIC against Enterobacteriaceae. Resistance Resistance to aminoglycosides includes production of aminoglycoside modifying enzymes (AMEs), alteration of the ribosomal target through production of 16S rRNA...
The antimicrobial resistance (AMR) phenomenon has been called “a slow tsunami” because it can blow away all available antibiotic treatments. The COVID-19 pandemic has significantly contributed to the rise of AMR [2] because of the increasing rate at which antibiotics were prescribed to ...
The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm’s excretory/secretory products (ESPs), which have a wide spectrum of biol
Single Dose versus no Antibiotic Prophylaxis in the Treatment of Acute Cholecystitis (PEANUTS II): Multicenter Randomized Non-inferiority Trialdoi:10.1016/j.hpb.2021.08.063W.G. van BraakSt. Antonius Hospital, Surgery, the NetherlandsJ.E. Ponten...
It’s difficult for me to admit that things have been just plain crappy. I’ve had infection after infection (pneumonia, kidney, cellulitis). Super antibiotic after super antibiotic. And I have zero energy. Just getting out of bed each day has been such a struggle. ...
Participants will receive 1 single dose as an injection under the skin (subcutaneous, s.c.) into the buttocks. Participants will have 3 visits with the study team. For each participant, the study will last up to 84 days. 显示全部
Antibiotic persistence describes the presence of phenotypic variants within an isogenic bacterial population that are transiently tolerant to antibiotic treatment. Perturbations of metabolic homeostasis can promote antibiotic persistence, but the precise mechanisms are not well understood. Here, we use laborator...
Who made you look good in front of your consultant when you did not know the correct antibiotic for meningitis and she whispered it into your ears as she walked out of the room? Who did all the dirty work in the labour room but allowed you to bring the baby to the mother? Who assist...