The IkappaB kinase complex in NF-kappaB regula- tion and beyond. EMBO Rep. 15, 46-61.Hinz M,Scheidereit C.The Ikappa B kinase complex in NFkappa B regulation and beyond[J].EMBO Reports,2014,15(1):46-61.M. Hinz, C. Scheidereit, The IkappaB kinase complex in NF-kappaB regulation...
研究 1.IκBα 在激活NF-κB 信号通路中的作用:当 同时发现,IκBα 基因缺陷小鼠皮肤基底细胞层发育 各种刺激因子(如脂多糖、病毒蛋白、氧自由基、 差,出现鳞片及腐肉,皮肤切片中非炎症性粒细胞 细胞因子)刺激细胞时,级联信号迅速激活IκB 激 明显增多,骨髓及脾脏中性粒前体细胞从出生后2 d 酶(IκB kinase,...
目的探究葛根素对创伤后应激障碍(posttraumatic stress disorder,PTSD)大鼠行为学,单胺类递质,炎症的影响,并从抑制性核因子激酶κB/核因子κB抑制剂α/核转录因子κB(inhibitory nuclear factor kinase-κB/inhibitor nuclear factor-κBα/nuclear transcription factor-κB,IKK/IκBα/NF-κB)通路分析其作用机制.方法将...
A large protein complex mediates the phosphorylation of the inhibitor of kappaB (IkappaB), which results in the activation of nuclear factor kappaB (NF-kap... E Zandi,Y Chen,M Karin - 《Science》 被引量: 1429发表: 1998年 TAK1 is critical for IkappaB kinase-mediated activation of the NF...
The IkappaB kinase (IKK) complex is a central component in the classic activation of the nuclear factor-kappaB (NF-kappaB) pathway. It has been reported to function in physiologic responses, including cell death and inflammation. We have shown that IKK is regulated by oxidative status after tra...
结论 亚砷酸钠可使HaCat细胞活力明显下降;诱导HaCat细胞Akt蛋白 的磷酸化活化,进而诱导其下游信号因子IKB磷酸化及核转录因子NF—KB入核表达。 关键词:亚砷酸钠;人角质形成细胞株;蛋白激酶B;IKB;NF—KB 中图分类号:R994.6 文献标志码:A 文章编号:1001—5914(2012)08—0700—04 Efectofsodiumarseniteon...
NF-κB、IκB、IKK在非小细胞肺癌中的表达及意义 赵统;吕坤聚;蒋捍东 【摘要】Objective To investigate the expression of NF-kappaB P65,p-IκBα and p-IKKβ in non-small cell lung cancer (NSCLC) in order to investigate their relationship with the clinical pathologic features of patients with ...
Processing of NF-κB2 precursor protein p100 to generate p52 is tightly controlled, which is important for proper function of NF-κB. Accordingly, constitutive processing of p100, caused by the loss of its C-terminal processing inhibitory domain due to nfκb2 gene rearrangements, is associated ...
蛋白激酶C是一组重要的细胞内信号转导物质, 它磷酸化下游 元件IκB,使其活化并分解小分子蛋白NF-κB,该小分子蛋白对淋巴细胞的活化,淋巴细胞的凋亡以及淋巴细胞介导的细胞毒作用有着重要的调控作用.NF-κB与IκB-α是一组相互调节的系统,其中一个成分调节水平的改变可影响另一个成分的活性;这些成分活性的改变又...
病理过程 中发挥重要作用.NF—xB的过度表达可 引起多种疾病.如炎症性疾病,哮喘,肺 纤维化,肿瘤和艾滋病等.IKB激酶(IKB kinase,IKK)作为NF—stB通路中重要的激 酶,其生物学特性及作用机制已成为研 究的热点. 1IKK/NF.KB信号转导途径 NF.KB蛋白家族在正常代谢和免疫 反应中起着非常重要的作用,NF—KB蛋 白...