In this work, we elucidated the downside of IFN-I during ICD. We demonstrated that IFN-I reprograms cancer cells toward a more aggressive, stem-like phenotype by upregulating KDM1B, an epigenetic regulator also known as LSD2, which erases mono- and dimethyls on histone H3 at lysine 4 (H3...
elucidated that MHC-I can directly inhibit the phagocytic activity of TAMs. B2M of the MHC-I molecules can combine with the inhibitory receptor LILRB1 on the surface of macrophages, protecting cancer cells from phagocytosis [40]. These researches provided new insights into the function of MHC-I...
(2013) have elucidated hydrocarbon-degrading bacterial communities from freshwater, marine, and hypersaline Brazilian aquatic ecosystems which were enriched with different hydrocarbons (heptadecane, naphthalene, or crude oil) based on 16S rRNA clone library and sequencing approach. The authors showed that ...
containing R173C-apoA-I (apoA-IMilano) have been shown to have potent regression activity in a human phase II clinical trial, although the mechanism by which this Anti atherosclerotic activity of V156K apoA I 161 remedy was affected has yet to be clearly elucidated (Nissen et al., 2003)....
yet been elucidated. Therefore, in this study, we considered Amuc_1409 as a potential probiotic factor and investigated its biological role and mechanism of action. Amuc_1409 promotes ISC-mediated epithelial development in intestinal organoids by activation of the Wnt/β-catenin signaling pathway ...
of several studies suggest that EBNA-LP plays an important role in the transformation of B cells that are responsible for co-activation of transcriptional activity of the viral LMP-1 protein, controlled by EBNA-2, the exact mechanism of action of this antigen has still not been elucidated.4...
It produced a multiplier effect and it elucidated strong interest worldwide in its use of the Internet with community broadcasting, its pioneering “radio-browsing” programmes and its multimedia community database for development. unesdoc.unesco.org 这一项 目产生了加倍的效果,并且引起全世界对其社区广...
Although the action mechanisms of IGF-I in neurons have not been fully elucidated, it has been shown that IGF-I stimulates the autophosphorylation of IGF-IR[53] in a different manner to insulin[54]. Furthermore, as it will be further discussed, we have reported a neuroprotective role for ...
Although aging is one of the main areas of interest for social policies and social services, it has not been possible to engage in interdisciplinary studies with cinema in these disciplines. Studies on the representation of aging in cinema have mainly been produced in the fields of sociology, fi...
However, whether the anti- inflammatory effect of apoA-I independently contributes to a reduction in atherosclerosis has not yet been revealed. Precisely what role apoA-I plays in modulating the inflam- matory response remains to be elucidated. Several studies have shown that the effect of LPS ...