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Finally, a genome-wide CRISPR–Cas9 loss-of-function screen in differential valine conditions identified several genes, including SLC7A5 and BCL2, whose genetic ablation or pharmacological inhibition synergized with valine restriction to reduce T-ALL growth. Our findings identify tRNA deregulation as a...
The concentration drop might be caused either by sudden changes in the PT conditions (which seems unlikely), the buffering of Y (HREE) by co-genetic minerals, such as gadolinite-(Y), or by melt–melt or fluid-melt immiscibility. Gadolinite-(Y) is one of the most common accessory ...
diameter by the respiratory supercomplex probably serves to minimize the volume, thereby potentially contributing to higher local concentration of electron carriers, ensuring that proton translocation results in an increased local proton motive force, ultimately optimizing conditions for ATP synthesis. This ...
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Under physiological conditions, renal tubule-glomerular feedback can regulate the tension of entering glomerular arterioles and maintain the stability of renal function; however, under the condition of hyperglycemia, the reabsorption of SGLT2-mediated sodium and glucose in renal proximal tubules increased,...
These examples have not been thoroughly tested under all conditions. IBM, therefore, cannot guarantee or imply reliability, serviceability, or function of these programs. The sample programs are provided "AS IS", without warranty of any kind. IBM shall not be liable for any damages arising out ...
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