Both applications use a novel simulation-based multiple testing correction procedure that is very flexible and less conservative than the traditional false discovery rate approach.Goovaerts, PierreGoovaerts P (2007) Spatial uncertainty in medical geography: a geostatistical perspective. In: Shekhar S, ...
Medical device manufacturers must ensure that their products reach end-users in a safe and functional condition as medical device manufacturers must ensure that their products reach end-users in a safe and functional condition. They are also required to employ validation protocols that will provide ev...
Hypothesis TestingExpected Net BenefitsThis work investigates whether to conduct a medical study from the point of view of the expected net benefit taking into account statistical power, time and cost. The hypothesis of this paper is that the expected net benefit is equal to zero. Methods: ...
In this article, we examine hypothesis-testing methods, assessing the performance of the Wald test without and with continuity corrections, and a score test based on a case-control study applied to TND data, with a focus on sparse data settings. We also compare the performance of their associa...
Before testing for phenomena, you form a hypothesis of what might be happening. Your hypothesis or guess about what's occurring might be that certain groups are different from each other, or that intelligence is not correlated with skin color, or that some treatment has an effect on an outcom...
Null Hypothesis Significance Testing (NHST) has been well criticised over the years yet remains a pillar of statistical inference. Although NHST is well described in terms of statistical models, most textbooks for non-statisticians present the null and alternative hypotheses (H0 and HA, respectively)...
2.2.3 Typical Independent Variables in HCI Research Independent variables are closely related to the specific research field. It is obvious that the factors frequently investigated in medical science are drastically different from those examined in physics or astronomy. In the HCI field, independent var...
Because such evidence could strengthen the concept that HDL is an actor rather than a bystander in atherogenesis, an important challenge for the coming years will be the translation of HDL function assays from bench to bedside. These assays are particularly needed in view of the ongoing testing ...
3. Bayesian hypothesis testing: An alternative to NHST "(…) prior and posterior are relative terms, referring to the data. Today's posterior is tomorrow's prior." Lindley [52, p. 301]. In the field of statistics, probabilities can be interpreted under two predominant paradigms: Frequentist...
Examples of a novel variant in a known gene and of a combinatorial effect are shown below. We conclude that, not only are the predictions significant on an independent dataset, but also largely non-redundant to those made by existing state-of-the-art methods, thus advancing the field. ...