The hypothalamus plays a significant role in the endocrine system. The function of the hypothalamus is to maintain your body’s internal balance, which is known as homeostasis. To do this, the hypothalamus helps stimulate or inhibit many of your body’s key processes, including: Heart rate and...
It has the pivotal role of driving the function of the downstream elements of the HPG axis. GnRH neurons express abundant GnRH mRNA transcripts, which ensure a persistent steady-state pool of the GnRH protein (Herbison, 2015). The GnRH gene encodes a larger propeptide that is cleaved into a...
Additionally, single-nucleus sequencing (nucSeq) has gained a lot of attention in recent years. The major advantage of nucSeq is removal of the time-consuming enzymatic cell-dissociation steps, which can potentially influence gene expression17. In addition, nucSeq can be performed on frozen tissue...
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A number of important nuclei with a role in autonomic function have been identified in the hypothalamus. A prime example of these nuclei is the paraventricular nucleus (PVN) of the hypothalamus. The PVN is a bilateral structure situated along the third ventricle that integrates and responds to a...
The autonomic nervous system is composed of the sympathetic nervous system (SNS) and parasympathetic nervous system (PNS), and these two branches have opposite effects on the function of the organs. A critical component of the central pathways mediating autonomic output is the paraventricular nucleus...
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While studies indicate that male mice may be more susceptible than females to the effects of a HFD on weight gain, metabolic changes, and cognitive function, the mechanisms at play in female mice could involve a more intricate and nuanced process [21,23]. Stress-induced eating, often observed...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
The maintenance of energy metabolism in brain cells is essential for normal brain function [1]. Thus, impaired metabolic activity can be used as a pathological sign for understanding the initiation and development of neurological disorders [2]. The hypothalamus is the central unit for controlling en...