Emmanuel Mignot, in Principles and Practice of Sleep Medicine (Fifth Edition), 2011 Hypocretin Studies Reports of third-ventricle lesions (hypothalamus and upper midbrain) in association with narcolepsy (such as tumors) have been described since the 1930s.147-153 Narcolepsy-like symptoms have also ...
as well as to the rapidity of the increase in lesion size. Slowly growing lesions tend to cause problems of hormone dysregulation rather than dramatic symptoms. Large, slowly growing lesions may cause more acute problems, such as when a slight increment in growth eliminates the remaining vestiges...
and sex can affect various aspects of health in mice. Specifically, we aimed to elucidate the neurobiology of underlying stress and metabolic dysfunction with a focus on sex-specific differences. We recognize that stress and metabolic disorders often co-occur and exhibit distinct patterns between sexe...
News Promising Therapeutic Target Uncovered to Treat Stress-Related Sleep Disorders News Neurons Involved in Chronic Stress Uncovered Drug Discovery Neurons Identified That May Contribute to Early Alzheimer’s Disease Symptoms News The Neural Circuit That Fuses Stress, Insomnia, and the Immune ...
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated Clinical and preclinical data suggest that unrestrained secretion of corticoctropin-releasing hormone (CRH) in the CNS produces several signs and symptoms ... As...
E. et al. Rapid improvement of acute schizophrenia symptoms after intravenous sodium nitroprusside: a randomized, double-blind, placebo-controlled trial. JAMA Psychiatry. 70, 668–676 (2013). Article CAS PubMed Google Scholar Shim, S., Shuman, M. & Duncan, E. An emerging role of cGMP in...
and gonadal signals to the neuroendocrine brain, and thus gate the onset of puberty and adult fertility. The putative involvement and therapeutic potential of NO in the pathophysiology of brain diseases, for which hormonal imbalances during postnatal development could be risk factors, is also ...
Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood CONTEXT: Evidence suggests that early adverse experiences play a preeminent role in development of mood and anxiety disorders and that corticotropin-releas... Heim,Christine - 《Jama the Journal ...
The Human Hypothalamus: Neuropsychiatric Disorders SusanPyner, inHandbook of Clinical Neurology, 2021 Introduction Thehypothalamusis part of thelimbic systemand is responsible for the regulation of a number of metabolic processes and other activities of the autonomic nervous system. A number of important...
However, there is no clear evidence for altered synaptic serotonin levels in untreated OCD and the response to SSRIs in this disorder is rather suggestive of decreased than increased serotonin levels. Moreover, acute tryptophan depletion failed to worsen OCD symptoms in treated as well as in ...