Case reports and the literature on the treatment of severe hyponatremia were reviewed. It appeared that the conflicting opinions with respect to the rate of correction of severe hyponatremia could be reduced to not differentiating between acute and chronic hyponatremia, to using different criteria for ...
Various formulas have been proposed to estimate an increase in serum [Na+] after administration of intravenous fluids,19 but they tend to underestimate the rate of correction.27 Therefore, during treatment with hypertonic saline, the patient should be monitored carefully for changes in neurologic and...
After sodium level has increased by the initial target of 4 to 6 mEq/L(4 to 6 mmol/L), the rate of correction is slowed so that serum sodium level does not rise by > 8 mEq/L (> 8 mmol/L) in the first 24 hours. Hypertonic saline solution Hypertonic (3%) saline (containing ...
When hyponatremia is caused by SIADH, hypertonic saline is indicated for acute, symptomatic cases, whereas fluid restriction is recommended to achieve a slower rate of correction for chronic asymptomatic hyponatremia. Pharmacological therapy may be necessary when fluid restriction is insufficient. The ...
One of the most concerning issues with the use of any V2 receptor antagonist in the treatment of hyponatremia is the rate of correction of serum [Na+]. While most patients were reported to do well with conivaptan, it is concerning to note that 5 out of 51 patients who received conivap...
Severe hyponatremia (<125 mEq/L) has a high mortality rate. In instances when the serum sodium level is <105 mEq/L, the mortality is >50%, especially in alcoholics. No sexual predilection exists for hyponatremia. However, symptoms are more likely to occur in young women than in men. The...
Both hyponatremia and its rapid correction can cause neurological disorders. Slowly correcting hyponatremia (especially when asymptomatic) at a rate of 0.5... FH Bender - 《American Journal of Kidney Diseases the Official Journal of the National Kidney Foundation》 被引量: 36发表: 1998年 Treatment ...
Cirrhotic patients with ascites and hyponatremia have a poor quality of life and high mortality [1]. One-year survival rate in these patients is less than 60% [2]. Development of ascites with or without hyponatremia is associated with multiple pathophysiological alteration, i.e. renal water and...
Rate of Sodium Correction and Osmotic Demyelination Syndrome in Severe Hyponatremia: A Meta-Analysis Current guidelines recommend limiting the rate of correction in patients with severe hyponatremia to avoid severe neurologic complications such as osmotic ... YS Xin,YC Chang,CY Peng,... - 《Journal...
Overly aggressive correction of serum sodium levels can result in neurological injury caused by osmotic demyelination. Therapeutic measures to lower the serum sodium level should be undertaken if the rate increases too rapidly.Mary AnsleyBuffington...