Examination of the single point mutants demonstrated that the M448V mutation was predominantly involved in the decrease in CoREST binding, as predicted by the structural model- ing (Supplementary information, Figure S1); the E413G mutant bound significantly more CoREST than the 2lox variant, but ...
Finally, variations in the penetrance and expressivity of the hypomorphic mutation may depend on a set of numerous factors, including developmental and environmental com- ponents: For example, the mutated Maoa-Neo chimeric transcript (or protein), albeit non-functional, may still serve other ...
Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task Article 03 January 2024 Explore related subjects Discover the latest articles, news and stories from top researchers in relat...