Heart failureCardiac myosin inhibitorsHeart transplantLeft ventricular assist deviceThere has been much debate surrounding novel medical therapies and heart transplantation listing challenges in patients with hypertrophic cardiomyopathy (HCM).#Recent clinical trials led to FDA approval of mavacamten (a ...
Heart Failure Due to Severe Hypertrophic Cardiomyopathy Reversed by Low Calorie, High Protein Dietary Adjustments in a Glycogen Storage Disease Type IIIa P... Heart failure due to severe hypertrophic cardiomyopathy reversed by low calorie, high protein dietary adjustments in a glycogen storage disease ...
Left ventricular twist mechanics in patients with apical hypertrophic cardiomyopathy: assessment with 2D speckle tracking echo- cardiography. Heart. 2010;96:49 -55.Left ventricular twist mechanics in patients with apical hypertrophic cardiomyopathy:assessment with2D speckle tracking echocardiography. Chang SA...
Omecamtiv mecarbil (a myosin activator) and mavacamten (a myosin inhibitor) have beneficial effects in patients with heart failure with reduced ejection fraction or obstructive hypertrophic cardiomyopathy, respectively.doi:10.1038/s41569-020-00488-yGregory B. Lim...
heart failure hypertrophic cardiomyopathy stroke sudden death surgery Abbreviations and Acronyms AF atrial fibrillation ASA alcohol septal ablation EF ejection fraction HCM hypertrophic cardiomyopathy HF heart failure ICD implantable cardioverter-defibrillator LGE late gadolinium enhancement LV left ventricular NYHA...
To ascertain relationships between modes of death and various pathological parameters in hypertrophic cardiomyopathy (HCM), quantitative analysis of the disarray, fibrosis, and size of myocytes was performed in 22 autopsied subjects with HCM. According to mode of death, the subjects were categorized as...
To evaluate the capability of MRI to differentiate cardiac amyloidosis (CA), end-stage hypertrophic cardiomyopathy (HCM), and hypertensive heart disease (HHD), which are important etiologies of left ventricular hypertrophy (LVH) and heart failure.We enrolled 26 patients presenting with both LVH and ...
Hypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder characterized by cardiomyocyte hypertrophy and cardiac fibrosis. Pathological cardiac remodeling in the myocardium of HCM patients may progress to heart failure. An in-depth elucidation of the lineage-specific changes in pathologic...
To evaluate the capability of MRI to differentiate cardiac amyloidosis (CA), end-stage hypertrophic cardiomyopathy (HCM), and hypertensive heart disease (HHD), which are important etiologies of left ventricular hypertrophy (LVH) and heart failure. Materials and methods We enrolled 26 patients presentin...
Familial Hypertrophic Cardiomyopathy (HCM) is the most common inherited cardiac disease. About 30% of the patients are heterozygous for mutations in the MYH7 gene encoding the ß-myosin heavy chain (MyHC). Hallmarks of HCM are cardiomyocyte disarray an