Hypertrophic cardiomyopathy: can the noninvasive diagnostic testing identify high risk patients? World J Cardiol. 2014;6(8):764–70. CentralZhang L, Mmagu O, Liu L, Li D, Fan Y, Baranchuk A, Kowey PR: Hypertrophic cardiomyopathy: can the noninvasive diagnostic testing identify high risk ...
HCM-causing actin mutations have also provided insight into the pathogenesis of cardiomyopathy. We have recently identified five actin mutations in HCM patients. Three mutations were de novo, present in patients but not in their parents, and were therefore responsible for apparently sporadic HCM. One...
Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy. J Am Coll Cardiol 2009;54(3):201-11.Bos JM, Towbin JA, Ackerman MJ. Diagnostic, prognostic, and therapeutic im- plications of genetic testing for hypertrophic cardiomyopathy. J Am Coll Car- ...
New diagnostic options in hypertrophic cardiomyopathyelectrical injuryelectrocardiogramarrhythmiasThe pathophysiologic features and clinical manifestations of HCM have been elucidated by the introduction of several new diagnostic options. Knowledge of the molecular defects of HCM has advanced rapidly, and genetic ...
Hypertrophic cardiomyopathy: clinical spectrum and treatment. Circulation.1995;92:1680-1692.Google Scholar 9. Maron BJ, Moller JH, Seidman CE. et al. Impact of laboratory molecular diagnosis on contemporary diagnostic criteria for genetically transmitted cardiovascular diseases: hypertrophic cardiomyopathy,...
How ishypertrophic cardiomyopathydiagnosed? Medical history, family history, a physical exam and diagnostic test results all factor into a diagnosis. A common diagnostic test is an echocardiogram that assesses the thickness of the heart muscle and observes blood flow from the heart. ...
Understanding the relationship between genotype and phenotype and exploring the mechanisms underlying the development of cardiomyopathy based on causative genes, are key to developing new therapeutic strategies. Over the past decade, significant advancements have been made in the diagnosis and treatment of ...
However, more limited hypertrophy (13–14 mm) can be diagnostic when present in family members of a patient with HCM or in conjunction with a positive genetic test. Hypertrophic cardiomyopathy is the most common inherited heart disease with a prevalence of 1:200 to 1:500 in the general ...
摘要: Case 1. A 51-year-old man with a past medical history significant for hypertension and hyperlipidemia was admitted for evaluation of chest pain. Diagnostic tests. Electrocardiography (￡CG) findings (Figure 1) were notable for left ventricular hypertrophy (LVH) with distinct secondary T-...
Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy. JAMA. 2007;298(4):405-41217652294ArticlePubMedGoogle ScholarCrossref 7. Maron BJ, Tajik AJ, Ruttenberg HD, et al. Hypertrophic cardiomyopathy in infants: clinical features and natural history....