A hallmark of diabetes is an absolute or relative reduction in the number of functional β cells. Therapies that could increase the number of endogenous β cells under diabetic conditions would be desirable. Prevalent gene targeting mouse models for assessing β-cell proliferation and diabetes pathogen...
Diabetes mellitus is marked by hyperglycemia and a variety of other metabolic disorders. The significance of hyperglycemia in the pathogenesis of diabetic retinopathy has proven difficult to evaluate in patients. Diabetic dogs are known to develop retinal lesions morphologically identical to those typical ...
Severe Hyperglycemia in an Insulin-Deficient Patient with Type 2 Diabetes Responding Well to Oral Antidiabetic TherapyGlucose toxicityglucotoxicityinsulin deficiencyinsulin treatmenttype 2 diabetesGLUCOSE TOXICITYMANAGEMENTMELLITUSASSOCIATIONSTATEMENTType 2 diabetes mellitus (T2DM) is a chronic, progressive disease...
Many autoimmune NOD (non-obese diabetic) murine studies have shown a beneficial effect of BCG or CFA (Complete Freund’s Adjuvant) in preventing the onset of autoimmune diabetes and even reversing full blown established disease in mice.17,18The NOD mouse is a well-studied spontaneous model of ...
To examine this possibility directly, we measured glucose uptake after 24 h of hyperglycemia (281 +/- 16 mg/dl) and normoglycemia (99 +/- 6 mg/dl) in 10 type I (insulin-dependent) diabetic patients (age 33 +/- 3 yr, relative body wt 102 +/- 3%) treated with continuous ...
Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled... OBJECTIVE--Dapagliflozin, a highly selective inhibitor of the renal sodium-glucose cotransporter-2, increases urinary excretion of glucose and ...
Hyperglycemia in poor controlled diabetes from crude tamarind herbal pill: a case study.: Hyperglycemia is an important finding in the diabetic patient with poo
In this study, we generated a stable enteroendocrine cell line expressing insulin under the control of the GIP promoter and showed that these cells produced insulin in a glucose-dependent manner. Transplantation of these cells into STZ-induced diabetic non-obese diabetic/severe combined immunodeficiency...
In static and dynamic in vitro conditions, such structures produced C-peptide after stimulation with high glucose. HLSC-ILS significantly reduced hyperglycemia and restored a normo-glycemic profile when implanted in streptozotocin-diabetic SCID mice. Diabetic mice expressed human C-peptide and very low...
Hyperglycemia is an important finding in the diabetic patient with poor glycemic control. There are several possible causes of hyperglycemic. Here, the author presents an interesting case study on a female diabetic patient presenting with hyperglycemic due to intake of crude tamarind herbal pill. Gener...