The critical analysis of the digital transformation domain influenced the formulation of five research hypotheses that frame digital transformation of digital transformation, as the second goal of this research article. Armed with a meta-modeling layer, the incremental development of hybrid architecture ...
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5g, h, Fig. S10). Consistent with our findings, mechanical strain in mesenchymal stem cells initiates a signaling cascade that is uniquely dependent on mTORC2 activation and phosphorylation of AKT at Ser-473, an effect sufficient to cause inactivation of GSK3β33. Fig. 5: The PLD2-mTORC2-...
5g). Of note, either suppression of PDK4 activity by PDK4-IN or knockdown of PDK4 via small hairpin RNAs (shRNAs) remarkably deprived cancer cells of these gain-of-functions conferred by PDK4+-stromal cell CM, substantiating the key role of PDK4 in governing the potential of PDK4+-...
Actuators mounted on the rear subframe connected to the toe control arm can rotate the rear suspension knuckle by up to 3.5º. At low speeds, the rear wheels turn in the opposite direction to the fronts, effectively reducing the wheelbase and therefore red...
Ultra-low-power rendering framework improves battery life and provides smoother animation effects; SOC integrated frequency modulation connects the hardware resources of the whole machine in series to respond to changes in computing power requirements faster, with fewer frame drops and smoother performance...
(h) Number of calcium transients showing ΔF/F0 > 0.04 in 5 dpf Tg[Huc:GCaMP5G] larvae at different time points following exposure to either 15 µM DFP (n = 4) or vehicle (n = 3) (two-way ANOVA with Sidak’s multiple comparisons test: n.s., non-significant; *...
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(B) Sequence of genomic DNA showing the C95G change in the human ORNT1 ORF from a control, parent (carrier), and affected HHH patient. Primers were designed to amplify the exon-intron regions covering the ORNT1 open reading frame (ORF), exons 2 through 7, based on genomic clone AL16...