Hylin-a1: a new weapon peptide against antibiotic-resistant bacteriadoi:10.4081/mm.2023.11373DRUG resistance in bacteriaPEPTIDESWEAPONSPEPTIDE antibioticsChianese, A.Zannella, C.Giugliano, R.Foglia, F.Della Marca, R.Ambrosino, A.Morone, M. V....
Considering the enormous therapeutic potential of Hylin-a1, further experiments are required to elucidate its mechanism of action and to increase its stability by modifying the native sequence.Chianese, AnnalisaZannella, CarlaMonti, AlessandraDoti, Nunzianna...
Hylin-a1 toxicity was evaluated on human keratinocytes; once the non-cytotoxic concentration range was determined, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were analyzed, and time-killing assays were performed to verify the bacteriostatic and/or bactericidal...