Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage. Chem Biol Interact. 193(3):232-9.DEIANA M,INCANI A,ROSA A,et al.Hydroxytyrosolglucuronides protect renal tubular epithelial cells against H2O2induced oxidative damage. Chemico Biological ...
0294 : Glucuronide metabolites of hydroxytyrosol are responsible for the antioxidative properties of olive oildoi:10.1016/S1878-6480(16)30403-7Hydroxytyrosol (HT) is known to be a strong polyphenolic antioxidant of olive oil. However, its in vivo effects are controversial since intestinal absorption ...
Hydroxytyrosol, hydroxytyrosol-3'-O-glucuronide, hydroxytyrosol-4'-O-glucuronide, hydroxytyrosol-3-O-sulphate, and homovanillic alcohol-4'-O-glucuronide were used as the target compounds. Using the FTA DMPK-A dried urine spot card under optimum conditions, with 5 mu L of preconcentrated urine ...
Hydroxytyrosol was dose-dependently (R2=0.95) absorbed and excreted in the urines mostly as a glucuronide conjugate. Further, the administration of an hydroxytyrosol-rich OMWW extract (10 mg/kg) to the rats was also associated with an increase of their plasma antioxidant capacity. Future ...
Hydroxytyrosol (HT) and Resveratrol (RES) are recognized as strong antioxidant polyphenolic compound. While RES antioxidative mechanisms are well known, those of HT are controversial because of its low intestinal absorption and its high metabolisation in glucuronides (GC), suggesting that these ...
Extensive uptake and metabolism of the olive oil phenolic hydroxytyrosol was observed using HepG2 cells as a model system of the human liver. The main metabolites were glucuronides, methylglucuronides and methyl conjugates, in agreement with data from human studies where methylated and glucuronida...
HT-sulphate and 3,4-dihydroxyphenylacetic acid (DOPAC)-sulphate were the main metabolites, followed by DOPAC and homovanillic acid (HVA). HT-glucuronide, DOPAC-glucuronide, HVA-glucuronide and HVA-sulphate were also detected. Postprandial oxidised-LDL concentrations decreased with HT-B. HT is a ...
Free Radic Antioxid 3:S34-S41S. Hajihashemi, and J.M.C. Geuns, "Radical scavenging activity of steviol glycosides, steviol glucuronide, hydroxytyrosol, metformin, aspirin and leaf extract of Stevia rebaudiana", Free Radicals and Antioxidants, vol. 3, pp 34-41, 2013....
In this study, an analytical method to determine T, HT and some of their phase II metabolites (sulphates and glucuronides) in cheese was developed and validated. Samples were extracted with an acidic mixture of MeOH/water 80/20 (v/v) and, after a low temperature clean-up, the extracts...
Sci. 2021, 11, 4763 2 of 13 from blood and distributed in the human body [7], metabolized, and quickly eliminated in urine mainly as glucuronide and sulfate [8]. Currently, hydroxytyrosol from different sources is available on the market. Its absorption and subsequent urine excretion may be...