17-beta-hydroxysteroid dehydrogenase-II inhibitors having the structural formula (I) wherein the phenyl group labeled A and the group -C(R4)(R6)Y are oriented cis to each other; W represents O or S; R1 represents -H or optionally substituted -(C1?-C4)alkyl; n represents 0 or an ...
11b-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17b-hydroxysteroid dehydrogenase-type 2. Biochem. Biophys. Res. Commun. 399, 215-220.Baker ME. 11Beta-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17beta-hydroxysteroid dehydrogenase-type 2. Biochem Biophys Res Commun ...
17 beta-Hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human breast 17 beta-hydroxysteroid dehydrogenases (17 beta-HSDs) are involved in the interconversion of biologically active and inactive sex steroids and are considere... N...
In the present study, we evaluated the expression and regulation of 17beta-hydroxysteroid dehydrogenase (17HSD) type 1 and type 2, cytochrome P450 aromatase (P450arom), and 20alpha-hydroxysteroid dehydrogenase (20HSD) in mature and pregnant rats. Immunohistochemical analysis of rat 17HSD type 1 ...
During storage at 4 °C, the 17β-hydroxysteroid dehydrogenase activity of human placental microsomes with estradiol-17β was more stable than that with testosterone. In order to evaluate the basis for this difference, kinetics with C18-, C19-, and C21-steroids as substrates and/or inhibitors ...
Human 17 beta-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, bo... T Puranen,M Poutanen,D Ghosh,... - 《Molecular Endocrinology》 被引量: 118发表: 1997年 Structural and biochemical characterization of ...
The expression of the 17 beta-hydroxysteroid dehydrogenase (17-HSD) gene in a series of human breast cancer cell lines was studied by Northern blot hybridization with a cDNA probe and by a time-resolved immunofluorometric assay using polyclonal antibodies against the enzyme protein. The 17-HSD en...
英文别名: Hydroxysteroid Dehydrogenase, 11-beta Type II中文名: 中文别名: CBNumber: CB8999704 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 2 Hydroxysteroid Dehydrogenase, 11-beta Type II 化学性质 安全信息Hydroxysteroid Dehydrogenase, 11-beta Type II 性质、用途与生产工艺 ...
Immunolocalization of 3 beta-hydroxysteroid dehydrogenase, cytochrome P450 17 alpha-hydroxylase/17,20-lyase and cytochrome P450 aromatase in the equine cor... The onset of equine chorionic gonadotrophin (eCG) secretion in pregnant mares is associated with an increase in luteal androgen and oestrogen pr...
Objective To investigate the expression of 17βhydroxysteroid dehydrogenase type 2(17βHSD2) in the eutopic endometrium and endometriotic tissue of endometriosis. 目的探讨17β-羟类固醇脱氢酶2(17βHSD2)在子宫内膜异位症(内异症)在位与异位内膜的表达与发病的关系。2...