We analyzed ocular findings from two patients (aged 49 and 60 years) with hydroxychloroquine (Plaquenil, Winthrop Pharmaceuticals, Division of Sterling Drug, Inc., New York, New York) retinopathy. Both patients were treated for systemic lupus erythematosus; one patient was treated with 400 to 800...
A subtle case of hydroxychloroquine retinopathy: spectral domain optical coherence tomography findingsOPTICAL coherence tomographyCOHERENCE (Optics)Eye is the official journal of the Royal College of Ophthalmologists. It aims to provide the practising ophthalmologist with information on the latest clinical and...
The most important predictors of hydroxychloroquine retinopathy are thought to be high-dose (>5 mg/kg) and long-term (>5 years) use, but existing evidence is limited to retrospective studies of prevalence data. Despite the wide-ranging benefits of hydroxychloroquine therapy for patients with SLE...
Hydroxychloroquineis not a general antiinflammatory agent. Its mechanism of action in arthritis is uncertain. It is noteworthy, however, that its side effects involve the CNS. This includes both ototoxicity and retinal damage. Since there is no epidemiological or immunohistochemical evidence to support ...
Retinopathy of prematurity Introduction Hydroxychloroquine (HCQ: trade name, Plaquenil) and chloroquine (CQ: trade name, Aralen) are drugs established in the treatment of autoimmune disease and skin disorders, but are also emerging as a treatment option in oncology and paediatric inflammatory disorders....
The macular changes are potentially serious and are related to dosage and length of time taking hydroxychloroquine. Advanced retinopathy is characterized by reduction of visual acuity and a "bulls eye" macular lesion which is absent in early involvement. 后面的我有空再翻译。
The most serious side effects of Hydroxychloroquine include ocular complications, such as corneal deposits and retinopathy, which can lead to visual disturbances and vision loss. The risk of retinal toxicity increases with high doses and long durations of use, particularly with cumulative doses higher...
Short-term toxicities include GI (nausea, vomiting, diarrhea), ocular (accommodation defects, benign corneal deposits, blurred vision, scotomas, night blindness, preretinopathy), dermatologic (rash, alopecia, skin pigmentation), and neurologic (headache, vertigo, insomnia) effects. Periodic ophthalmologic...
Figure 1 Eight consecutive 10-2 visual fields with a white target in a patient taking hydroxychloroquine without retinopathy. Note: Point scotomas are common and do not persist.Abbreviations: MD, mean deviation; PSD, pattern standard deviation; SITA, Swedish Interactive Thresholding Algorithm; FN, fa...
Hydroxychloroquine retinopathy: screening and geneticsHealth servicesMedical imagingRetinal diseasesdoi:10.1038/s41433-020-0976-zF. H. ZaidiC. A. RennieA. K. DrinkwaterD. SahuE. AkyolA. J. LoteryEye