We showed here that JNJ7777120 (H4R antagonist), dexamethasone (anti-inflammatory steroid), suplatast tosilate (Th2-cytokine inhibitor), and anti-TSLP antibody all reduced the allergic ear swelling seen after a second challenge, whereas pyrilamine (H1R antagonist) and cromolyn (mast-cell stabilizer...
In addition, the present invention demonstrates a substantially greater bioavailability than a standard cream vehicle containing over twice the active ingredient. These results are remarkable in comparison to what would be expected by simply utilizing the prior antiperspirant technology. In one practice ...
32and, similar to HQ, is used for treatment of skin hyperpigmentation, robustly activates TRPA1 and causes irritation as well33. While zinc likely affects melanocytes directly, it remains to be investigated whether TRPA1 activation is essential for the skin lightening effects of both zinc and HQ,...
Disclosed is a hydroquinone derivative or a pharmaceutically acceptable salt thereof, the hydroquinone derivative being represented by formula (I): ##STR1## wherein R1 is a phenyl group whi