(2013) Dissecting the hydrophobic effect on the molecular level: the role of water, enthalpy, and entropy in ligand binding to thermolysin. Angew. Chem., Int. Ed. 52, 1822-1828.Biela, A.; Nasief, N. N.; Betz, M.; Heine, A.; Hangauer, D.; Klebe, G. Dissecting the Hydrophobic...
doi:10.1002/chin.198047081ABRAHAM M. H.WILEY‐VCH Verlag GmbHChemischer InformationsdienstAbraham, M.H. (1980) Hydrophobic effect of the methylene group: enthalpy and entropy contributions. J. Am. Chem. Soc. 102: pp. 5910-5912M. H. Abraham, J. Am. Chem. Soc. 102 (18), 5910 (1980)....
6.04.4Hydrophobic Effect The enigma of thehydrophobic effect—a combination of the cohesive nature of water (itself a function of the small size of water and its strong intermolecular hydrogen bonding) andvan der Waals interactionsbetween solutes—is capable of driving the formation of many supramole...
If they were distributed evenly, there would be a higher surface area and therefore amount of 'cage' water molecules and non-polar solutes would be more restricted in their movement (trapped in a polar environment). This is the entropic factor that drives the hydrophobic effect. I...
When phosphatidylcholine is suspended in water, the molecules associate by the hydrophobic effect, with the charged portion facing the solvent and the fatty acid side chains associating with each other. Instead of making a micelle, however, as palmitate does, these molecules associate into abilayer,...
solute clustering becomes less entropy driven than enthalpy driven. The energy needed to form cavities in a cohesive solvent like water explains the low solubility of lipophilic solutes in water, and their preference for lipophilic media. In addition, a distinction was introduced between ‘‘bulk’’...
entropy upon dissolving in water. It should also be mentioned in this context that pressure increases the solubility. The effect of pressure on the entropy was examined and it was found that increase in the pressure causes a reduction of orientational correlations, in agreement with the idea of...
How does the hydrophobic effect increase entropy? What factors affect the fluidity of an animal's cell membranes? What causes surface tension? Define dispersion forces. Describe salting out and its relationship to the hydrophobic effect. What is the principle of osmosis?
The energy and entropy associated with the H-bonding network can extend over a much larger region of space than the molecular correlations (Pauling, 1935; Hollins, 1964), and the perturbation of this network when water is under confinement could be at the root of the hydrophobic interaction....
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