carboxylic acidschiral pharmaceutical intermediatesnitrilasesnitrile hydrolysisSummary This chapter contains sections titled: Introduction Nitrilases Nitrilase-Containing Biocatalysts for Hydrolysis of Nitriles to Acids Summary and Outlook ReferencesSteffen Oßwald...
12. The process of claim 11 wherein said catalyst loading ranges from about 1 to 10 weight percent. Description: BACKGROUND OF THE INVENTION The hydrolysis of nitriles to form the corresponding amides in the presence of acids and bases is well known to those skilled in the art as noted in...
carboxylic amides (benzene compoundshydration, dehydrationWe describe here an efficient, rapid and selective method for the conversion of nitriles in to their corresponding amides in the presence of PEG-400, aqueous sodium hydroxide system under microwave irradiation.doi:10.1080/00397910008087213...
摘要: Cupreous catalysts prepared by reducing a mixture consisting essentially of copper oxide in combination with certain metal oxides have been discovered to be excellent heterogeneous catalysts for the hydration of nitriles to the corresponding amide....
Hydrolysis of Nitriles Using an Immobilized Nitrilase: Applications to the Synthesis of Methionine Hydroxy Analogue Derivatives Mild and selective hydrolysis of a large range of nitriles leading to carboxylic acids was achieved under neutral conditions by an immobilized and genetica... P Rey,JC Rossi...
Cohen MA, Sawden J, Turner NJ, Selective hydrolysis of nitriles under mild conditions by an enzyme, Tetrahedron Lett. 1990, 31, 7223-7226.Cohen MA, Sawden J, Turner NJ (1990). Selective hydrolysis of nitriles under mild conditions by an enzyme. Tetrahedron Lett. 31: 7223- 7226....
Nitrilase-Catalyzed Selective Hydrolysis of Dinitriles and Green Access to the Cyanocarboxylic Acids of Pharmaceutical Importance To further explore its synthetic applications, the nitrilase bll6402 from strain USDA110 has been examined toward the hydrolysis of various dinitriles. It ... D Zhu,C Muk...
Chemoselective hydrolysis of nitriles using tetrahalophthalic acids et al. " Hydrolysis in the Absence of Bulk Water 1. Chemoselective Hydrolysis of Amides using Tetrahalophthalic Anhydrides " Tetrahedron Lett., 1988, pp... WD Rounds,JT Eaton,JH Urbanowicz,... - 《Tetrahedron Letters》 被引量:...
process for the preparation of amides by enzymatic hydrolysis of nitriles. Nitriles constitute a unique class of compounds in organic chemistry. However, one of the drawbacks of conversion of nitriles is that they are generally resistant to hydrolysis, and hence, rather drastic reaction conditions ...
Nitrile-hydrating enzymes produced by bacteria and fungi catalyse the conversion of a large number of chemically diverse nitriles, including many economically important compounds used industrially for chemical synthesis of amides and acids. This paper presents data on two new, highly different nitrile-hy...