Selective quasi-hydrolysis of cyano group in 6-hydroxypiperidine-3,4,4-tricarbonitrilesReactions of 3,3-dialkyl-4-oxoalkane-1,1,2,2-tetracarbonitriles with water in the presence of pyruvic acid are accompanied by selective quasi-hydrolysis of cyano groups in intermediate 6-hydroxypiperidine-3,4,...
A scheme for the unusually ready selective hydrolysis of three of the cyano groups in 1,1,2,2-tetracyanoethane to 2-cyanoethane-1,1,2-tricarboxamide by the action of pyruvic acid was proposed. Only one cyano group undergoes hydrolysis in the reaction with sodium pyruvate. In the course of...
Bifunctional group participated nitrile group hydrolyzing enzyme model systems: Hydrolysis of the nitrile group of α-aminophenylacetonitrile to phenylglyc... Several nitrilases were screened for the hydrolysis of the nitrile group of cis-1,2-dihydroxy-3-cyanocyclohexa-3,5-diene and trans-3-[(5S,...
Compounds of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a trihalomethyl group, an alkyl group, or a cyano group, Y is a hydrogen a... HO Bayer,C Swithenbank 被引量: 0发表: 1982年 The 3,4-dichloroanilides of thiobutyric and isothiobutyric acids and com...
Preparation of some new neoglycoproteins by amidination of bovine serum albumin using 2-imino-2-methoxyethyl 1-thioglycosides. The cyanomethyl 1-thioglycosides of beta-D-galactose, 6-O-methyl-beta-D-galactose, alpha-L-arabinose, beta-D-fucose, beta-L-fucose, beta-D-glucose, beta-D-... ...
o-Acylbenzonitriles: Synthesis and Heterocyclization under Acid Hydrolysis of the Cyano Group 2-Cyanobenzophenones were synthesized by reaction of 2-bromobenzophenones with copper(I) cyanide in DMF, and their transformations involving acid hydrolysis of the cyano group were studied. Reactions... SS...
Bioinformatics of cyanophycin metabolism genes and characterization of promiscuous isoaspartyl dipeptidases that catalyze the final step of cyanophycin degradation Article Open access 23 May 2023 Introduction β-Carboline alkaloids comprise a large group of indole alkaloids. They are widely distributed se...
Tumor growth inhibition was calculated as TGI%=(1-(mean tumor volume of the treatment group on the first day-mean tumor volume of the treatment group on the end day)/(mean tumor volume of the control group on the first day-mean tumor volume of the control group on the end day)) ×...
aralkyl, heteroarylalkyl, alkaryl, alkheteroaryl, wherein at least one radical R is not hydrogen and the radicals R · 1 · R · 6 · optionally themselves and independently with one or more of the above group and by alkoxy, aryloxy , Hetaryloxy, alkylthio, arylthio, hetarylthio, acyl...
Our previous work showed that the protease activity of LonP1 is inhibited by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its methyl derivative CDDO-Me (also known as bardoxolone-methyl) (Fig. 1A) (15). These compounds have been shown to pro...