Perrin L, Werkema EL, Eisenstein O, Andersen RA (2014) Two [1,2,4-(Me3C)3C5H2]2CeH molecules are involved in the hydrogenation of pyridine to piperidine as shown by experiments and calculations. Inorg Chem 53:6361-6373Perrin, L., Werkema, E. L., Eisenstein, O. & Andersen, R. A...
Hydrogenation of Pyridine to Piperidine Catalyst (1) Isopropylamine synthesis catalyst (1) Ethylamine Synthesis catalyst (1) Morpholine synthesis catalysts (1) Cyclohexylamine catalyst (1) Isopropanol synthesis catalyst (3) Solid Phosphoric Acid Catalyst ...
Piperidines are one of the most widely used building blocks in the synthesis of pharmaceutical and agrochemical compounds. The hydrogenation of pyridines is a convenient method to synthesise such compounds as it only requires reactant, catalyst, and a hydrogen source. However, this reaction still re...
Thereby it is smoothly converted into piperidine. Example 2 40 100 parts by weight of crude dry pyridine are stirred together with 3 to 5 parts by weight of powdered sodium amide for several hours at ordinary temperature. The pyridine after the impurities have settled is taken off and is ...
in which deprotonation at the 2-(pyridyl)methylene unit in the (P,Npy, P)Ru pincer complexes induces an active catalyst30, has had a great impact on the ensuing molecular design of hydrogenation catalysts (py = pyridine;Npy = pyridine nitrogen). Iron (Fe) complexes catalyze the C...
showed that the increase in the concentration of3ahover time is consistent with the consumption of3u(Fig.4b). Interestingly,3uis stable toward 2, 6-dimethylpyridine-3, 5-dicarboxylate. These results demonstrate that3uis a mild organo-hydride reagent, and its hydride-donating ability (ΔHH-) ...
•TheHoofhydrogenation,alsoknownastheheatofhydrogenation,canbeusedasameasureoftherelativestabilityoftwodifferentalkenesthatarehydrogenatedtoformthesamealkane.•Whenhydrogenationoftwoalkenesgivesthesamealkane,themorestablealkenehasthesmallerheatofhydrogenation.5 6 •Themechanismexplainstwofactsabouthydrogenation:7...
10 It is noteworthy that some of the synthetic chiral catalysts, which are much smaller and simpler than enzymes, exhibit activities and selectivities comparable to those of enzymes.11, 12 Zhou et al. has recently reported a new type of chiral iridium catalysts bearing a spiro pyridine–amino...
Using the previously described (py)3RhCl3–NaBH4 catalyst in dimethylformamide with hydrogen, azobenzene is reduced to hydrazobenzene and slowly to aniline, benzalaniline gives benzylaniline, and nitrobenzene is reduced to aniline; pyridine and quinoline are hydrogenated to give piperidine and 1,2,3,...
(177 g). The receiver was removed and the condenser was configured to perform as reflux condenser. A caustic scrubber was attached and pyridine (0.9 g, 11 mmol) was added. Thionyl chloride (52.1 g, 438 mmol) was added over about 10 minutes, with evolution of white fumes. The reactor ...