A hypothesis is postulated that high content of hydrogen donors and acceptors, and basic amino acids cause the intracellular trapping of the H+ and Cl− ions, which increases cancer risks as local formation of HCl is mutagenic to DNA. Other cations such as Ca2+, and weak acids such as sh...
A hypothesis is postulated that high content of hydrogen donors and acceptors, and basic amino acids cause the intracellular trapping of the H+ and Cl- ions, which increases cancer risks as local formation of HCI is mutagenic to DNA. Other cations such as Ca2+, and weak acids such as ...
volving riboflavine Donors and acceptors of hydrogen in oxidation-reduction reactions involving riboflavineDonors and acceptors of hydrogen in oxidation-reduction reactions involving riboflavineKolesnikov, P A
Hydrogen Bonds in Proteins Hydrogen bonding is a vital feature of proteins and is necessary for maintaining: [1–4] Structure. Folding status. Stability. Selectivity and affinity towards ligands. Proteins contain many hydrogen bond donors and acceptors, including amide (-NH) donors and carbonyl (-...
hydrogen bond A chemical bond in which a hydrogen atom that is already bonded to an atom in a molecule forms a second bond with another atom, either in the same molecule or in a different one. The second atom is usually of a type that strongly attracts electrons, such as nitrogen or ox...
The former case is considered intramolecular hydrogen bonding while it is intermolecular in the latter case. The molecules contributing hydrogen atom (i.e., hydrogen bond donors), as well as the other electronegative participant molecules (i.e., hydrogen bond acceptors), are characterized by a ...
We have analysed the frequency with which potential hydrogen bond donors and acceptors are satisfied in protein molecules. There are a small percentage of ... Ian,K.,McDonald,... - 《Journal of Molecular Biology》 被引量: 3796发表: 1994年 Crystal structure of a p53 tumor suppressor-DNA com...
These results indicate that all of the oxygen and hydrogen atoms in apigenin can be hydrogen-bond acceptors and donors and that the oxygen and hydrogen atoms in the hydroxyl groups may be the preferred interaction sites over the other oxygen and hydrogen atoms. The carbon atom C9 has the ...
(e.g. indole) acting as donors or acceptors [38,39]. When the electronegative atoms D and A become closer, the barrier for transfer of the H atom between D and A is lowered. It can eventually become low enough so that the zero-point energy (ZPE) level (seeSection 2.1) lies above ...
The efficiency and selectivity of hydrogen atom transfer from organic molecules are often difficult to control in the presence of multiple potential hydrogen atom donors and acceptors. Here, we describe the mechanistic evaluation of a mode of catalytic activation that accomplishes the highly selective ...