Owing to the large num- ber of amines and thiol groups presented in its structure, the PDA components within the hydrogel were able to immo- bilize proteins or GFs via covalent and non-covalent bonds. Therefore, the sustained release of BMP-2 was achieved from the hydrogel, reaching a ...
6: due to the lower density of covalent cross-linking bonds in PAM, the three-dimensional network of PAM was loose and easily deformed and broken; although the mechanical strength of hydrogel-sample was enhanced after introducing only AlgSr into gel to form another extra-Sr2+-crosslink, the ...
(Supplementary Tables3and4). Indeed, the polyacrylic hydrogel in this work contains hydrogen-bonding and covalently crosslinked networks, which is similar to the hydrogel work bySuoet al.21. The covalent network is formed by crosslinking of the vinyl groups in acrylic acid and in vinyl-...
As expected, in-situ gelation can be achieved facilely and rapidly (tens of seconds) in PBS solution via forming covalent amide bonds by homogeneously mixing PASP, PAHy, and biocompatible catalysts, EDC/NHS, coupling physical crosslinks (ionic bond and hydrogen bond) under physiological conditions ...
As per the experimental basis carried out here, we propose a nanocomposite hydrogel having covalent as well as physical crosslinking. The sonic wave assisted exfoliated graphene platelets were successfully affect the strength of the hydrogel. Additionally the nanoplatelets enhances the unique features like...
2) Multi-material crosslinking may lead to heterogeneity and cytotoxicity after degradation. 5.1.1.1. Physical crosslinking Physical crosslinking hydrogels are crosslinked through non-covalent interactions, offering advantages such as low cost, low cytotoxicity, and strong self-healing ability [123]. ...
The term “covalently crosslinked” as used herein with respect to a polymer matrix refers to the formation of covalent bonds between reactive polymers within a hydrogel which are stable in the presence of an ionic solution (e.g. a sodium chloride solution at a concentration of about 1-2 M)...
immobilized AAMs, forming what are in effect non- covalent ‘crosslinks’. As free analyte from a body fluid or test solution diffuses into the hydrogel, binding competition displaces immobilized AAMs from ABMs, thus reducing the number of ‘crosslinks’. This reduction in crosslinking causes ...
The term “hydrogel” refers to a water-swellable polymeric matrix, consisting of a three-dimensional network of macromolecules held together by covalent or non-covalent crosslinks, that can absorb a substantial amount of water to form an elastic gel. ...
A crosslinked molecule may be crosslinked via an ionic or covalent bond, a physical force, or other attraction. A covalent crosslink, however, will typically offer stability and predictability in reactant product architecture. In some embodiments, each precursor is multifunctional, meaning that it ...