sequential asymmetric reactionHydroboration of alkynes provides a most straightforward, atom〆conomical, and convenient methodology to access alkenylboronic esters which have a wide range of applications in organic synthesis. Several efficient successful metalヽatalyzed methods have been developed for ...
Analogously, hydroboration of alkynes with HBcat or HBpin was catalyzed by dicyclohexylborane (5 mol%)182 at room temperature (Equation (13)). Dicyclohexylborane was also an effective catalyst for the monohydroboration of haloalkynes with 9-BBN (Equation (14)).183 The reaction was over within ...
在硼氢化之后再进行不同的处理可以得到不同的产物。 Scheme 7 | Hydroboration of alkynes and work up 当发生消除反应时,发生的是反式消除,并且卤素的加成也是反式加成: Scheme 8 | Anti-addition of bromine followed by a anti-elimination of bromide and boron 如果用水处理,可以先得...
Borane-Catalysed Hydroboration of Alkynes and Alkenes N. W. J. Ang, C. S. Buettner, S. Docherty, A. Bismuto, J. R. Carney, J. H. Docherty, M. J. Cowley, S. P. Thomas,Synthesis,2018,50, 803-808. Preparation of (E)-1-Alkenylboronic Acid Pinacol Esters via Transfer of Alkenyl ...
& Lu, Z. Asymmetric remote C-H borylation of internal alkenes via alkene isomerization. Nat. Commun. 9, 3939 (2018). PubMed PubMed Central Google Scholar Gao, D.-W. et al. Cascade CuH-catalysed conversion of alkynes into enantioenriched 1,1-disubstituted products. Nat. Catal. 3, 23–...
of the in situ formation of the key terminal alkenylBdan intermediate, followed by second enantioenriched hydroboration with HBpin (Bpin, pinacolato) with two steps sharing one catalytic system. This reaction is compatible with terminal alkynes with a variety of substituents (including aliphatic and ...
This protocol exhibits a broad substrate scope, as both internal and terminal alkynes were compatible. The synthetic value of this method was further demonstrated by its applicability in the late-stage modification of bioactive molecules. A preliminary mechanism for this reaction was proposed. Download...
& Lu, Z. Asymmetric remote C-H borylation of internal alkenes via alkene isomerization. Nat. Commun. 9, 3939 (2018). PubMed PubMed Central Google Scholar Gao, D.-W. et al. Cascade CuH-catalysed conversion of alkynes into enantioenriched 1,1-disubstituted products. Nat. Catal. 3, 23–...
PROCESS FOR THE HYDROBORATION OF ALKENES AND ALKYNESnot available for EP0212708 of corresponding document: US4731463 In a process for hydroboronizing alkenes or alkynes with catecholborane (1,3,2-benzodioxaborolane) optionally in the presence of an added organic solvent the reaction is catalyzed by...
A masked diboron in Cu-catalysed borylation reaction: highly regioselective formal hydroboration of alkynes for synthesis of branched alkenylborons. The use of a masked diboron as a boron source in the presence of a Cu--N-heterocyclic carbene (NHC) catalyst enables alkyl-, aryl-, heteroatom- an...