Hydrazone-doxorubicin,即阿霉素-腙键偶联物,是一种将药物阿霉素(Doxorubicin)通过腙键(Hydrazone bond)与其他载体(如葡聚糖、磷脂等)偶联而成的前药系统。这种设计的主要目的是改善阿霉素的药代动力学特性,降低其系统毒性,并增强其在肿瘤部位的靶向性和疗效。 结构特点: 阿霉素:一种蒽环类抗生素,广泛用于治疗各种类型...
hydrazone bond 翻译 腙键 以上结果来自机器翻译。
Method for cutting azine and hydrazone bondThe present invention relates to a kind of production hydrazine hydrate, replace hydrazine or amino-compound, the method is characterized in that, by hydrolyzing the azine of ketone, hydrazone or schiff base compounds in carbon dioxide sub critical, over...
Hydrogen Bond Acceptor Count:2 Topological Polar Surface Area:15.6 Heavy Atom Count::11 Defined Atom Stereocenter Count:0 Undefined Atom Stereocenter Count:0 Defined Bond Stereocenter Count:1 Undefined Bond Stereocenter Count:0 Isotope Atom Count:0 Covalently-Bonded Unit Count:1 CACTVS Substructure ...
A hydrogen peak of the hydrazone bond is detected by 1H NMR at δ 8.53 ppm [66]. In addition, the absorption around 1618 cm−1 in the FT-IR spectrum often supports the formation of the hydrazone bond [67]. Farnesol is a natural sesquiterpene, and farnesal is a derivative of farnesol...
) for the remaining 60 ml (60 column volumes) of effluent. Therefore, there appears to be a slow but continuous leakage from the gel. Other evidence indicates that this is not a breaking of the hydrazone bond under these conditions but is most probably a breaking of the gel/spacer bond....
Hydrogen Bond Acceptor Count:2 Topological Polar Surface Area:29.8 Heavy Atom Count::13 Defined Atom Stereocenter Count:0 Undefined Atom Stereocenter Count:0 Defined Bond Stereocenter Count:0 Undefined Bond Stereocenter Count:0 Isotope Atom Count:0 Covalently-Bonded Unit Count:3 CACTVS Substructure ...
Reaction of carbonyl with hydrazinegives a hydrazone. Hydrazine is more nucleophilic than a regular amine due to the presence of the adjacent nitrogen. Note the similarity to theformation of an oximereaction. Hydrazones generally form a mixture of geometric isomers. ...
In addition, the numbers of hydrogen bond donors and acceptors of the 13 derivatives were less than 5 and 10, respectively. Hence, all derivatives synthesized here sat- isfy Lipinski's rule. Collectively, these results suggest that derivatives of 4-chromenone combined with N-acylhydrazone could ...
Hydrogen Bond Donor Count:1 Hydrogen Bond Acceptor Count:2 Topological Polar Surface Area:38.4 Heavy Atom Count::3 Defined Atom Stereocenter Count:0 Undefined Atom Stereocenter Count:0 Defined Bond Stereocenter Count:0 Undefined Bond Stereocenter Count:0 Isotope Atom Count:0 Covalently-Bonded Unit...