The invention provides a diacylhydrazone bond for bridging polypeptide used for delivering an aldehyde derivative drug and relates to a pH response type diacylhydrazone bond. The invention relates to a new chemical bond. Different from the traditional mono-acylhydrazone bond, the PTA-linkers have ...
It remained stable for 24 h under a physiological condition (pH 7.4), but the rate and the degree of cleaving the hydrazone bond increased significantly at pH 5.3 [68]. Proteins have been used as nano-DDSs because of their excellent properties. Keratin is one of the most abundant proteins ...
Product Name: Distearoylphosphatidylethanolamine hydrazone bond polyethylene glycol alkynyl Synonyms: Distearoylphosphatidylethanolamine hydrazone bond polyethylene glycol alkynyl CAS: MF: MW: 0 EINECS: Mol File: Mol File Information Error Report Your Email: Browse...
HMF containing aldehyde group can be covalently captured by hydrazine group around magnetic bead through the formation of hydrazone bond, so as to inhibit the immobilization of hybrid duplex and the occurrence of TSDC. Thereby, HMF will cause the change of the fluorescence of modified magnetic bead...
Determination of doxorubicin amount conjugated to mPEG-b-PCL copolymer via pH sensitive hydrazone bond 来自 EBSCO 喜欢 0 阅读量: 3 作者:G Iik,A Tezcaner,N Hasirci,A Kiziltay 摘要: Objective: The aim of this study was to find the efficient medium to bind an anticancer drug, Doxorubicin (...
We report a series of acylhydrazone‐based switches, of which double bond rotation can be stimulated by a pH response. The switches prefer Z rather than E configuration in the ground state because of the intramolecular hydrogen bonding, which was analyzed both thermodynamically and kinetically. ...
obtained from the crystallographic data and indicate that conjugation between the hydrazone region and the phenyl rings plays a significant role in favoring a planar molecular conformation and has a significant perturbing influence on the bond lengths and angles associated with the hydrazone C=N-N ...
Hydrogen bonding and bond order in phenylhydrazones: structures of diethyl 2-(o-methylphenylhydrazono)-3-oxopentanedioate (1) and two forms [one monoclinic (2a), one orthorhombic (2b)] of diethyl 2-(p-nitrophenylhydrazono)-3-oxopentanedioate...
) for the remaining 60 ml (60 column volumes) of effluent. Therefore, there appears to be a slow but continuous leakage from the gel. Other evidence indicates that this is not a breaking of the hydrazone bond under these conditions but is most probably a breaking of the gel/spacer bond....
The reaction channel involving carbon-nitrogen bond cleavage is replaced by a pathway involving nitrogen-nitrogen bond cleavage in the presence of an added proton donor. The final reduction product by this route is FlHNH2. Fl=N−N=Fl is reduced stepwise and reversibly to its dianion in an ...