Mechanism of action The enzyme monoamine oxidase is localized to the outer membranes of the mitochondria that are present in nerve terminals containing noradrenaline, dopamine and 5-hydroxytryptamine. The enzyme inactivates the amine neurotransmitters by oxidative deamination, thus regulating the intraneurona...
Chemistry and Mechanism of Action: Procarbazine is a substitutedhydrazine derivativewith a chemical structure similar to that of the monoamine oxidase inhibitors (MAOIs). Accordingly, procarbazine exhibits weak MAOI effects. Procarbazine itself is inert and must undergo metabolic activation to generate cyto...
The mode of action of arylhydrazines on kojic acid was investigated. Some novel types of compounds were isolated, and their structures were determined. The mechanism of the reactions is discussed.doi:10.1080/07328308908048576El Sayed H. El Ashry...
The mechanism of action in chemical synthesis involves the transfer of hydrogen atoms from hydrazine dihydrochloride to the reactant, resulting in the reduction of the reactant and the formation of the desired product. Rocket Propellant: Hydrazine dihydrochloride is also used as a component in ...
The mechanism of action in chemical synthesis involves the transfer of hydrogen atoms from hydrazine acetate to other molecules, resulting in the formation of new chemical bonds. Pharmaceutical Industry: Hydrazine acetate has applications in the pharmaceutical industry. It is used as an intermediate ...
1. The paper discusses QSAR and mechanism of action of diacylhydrazines. 介绍了二芳甲酰基肼类昆虫生长调节剂的构效关系和作用机理。2) dibenzoylhydrazine 二芳酰基肼 1. This review is related to the progress of dibenzoylhydrazine over ten articles,and the relationship between their structure and...
2. The reaction of hydrazine with endogenous alpha-keto acids such as vitamin B, (pyridoxine). The formation of hydrazones of pyridoxine is the proposed mechanism by which hydrazine produces the neurological effects observed after exposure.
Current values are 0.01 ppm and a carcinogen status of A3 (designation A3: Carcinogenic in experimental animals at relatively high dose, by route(s) of administration, at site(s), of histologic type(s), or by mechanism(s) that are not considered relevant to worker exposure). Available ...
3 The second-order reaction between enzyme and phenylhydrazine is competitive with the second-order reduction of the enzyme by substrate, supporting the idea that Schiff-base formation between substrate and enzyme-bound pyridoxal phosphate is an obligatory step in the catalytic mechanism. Hence it ...
It was sought to elucidate the mechanism by which anaemia is caused in vitamin B6 deficiency. The experimental methods with pigs were previously described ... GE Cartwright,MM Wintrobe,S Humphreys - 《Journal of Biological Chemistry》 被引量: 47发表: 1944年 Hemmung der Monoaminoxydase durch ba...