Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in t... For the purpose of a side-effect monitoring of isoniazid (INH), we investigated the relationship between the genotypes of drug-metabolizi...
HumansCricetulusRatsCells, CulturedCell LineHydrazinesXenopus laevisTime FactorsThis study was designed to elucidate the cellular effects of hydrazine on four established tissue culture vertebrate cell lines (rat kangaroo kidney, Xenopus toad kidney, human diploid fibroblast, and Chinese hamster cells) and...
and hydrazides are known to be hepatotoxic causing hepatic necrosis via unclear mechanisms that may progress to acute liver failure. Variable sensitivity to the hepatic effects is thought to be related to the efficiency of liver acetyl transferase enzymes. Hydrazines exert oxidant stress on hemoglobin...
To explore deeper insight about the reaction mechanisms, the bonds taking part in reactions were analyzed based on the natural bond orbital, NBO, and the atoms in molecule, AIM, analyses at the UMP2/aTZ level. Also, the thermodynamic parameters of the predicted adducts were computed in the te...
Adverse Effects Toxic Pneumonitis Yes Methemoglobinemia MetHgb is secondary toxic effect Neurotoxin Other CNS neurotoxin Hepatotoxin Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion Dermatotoxin Skin burns Diseases, Processes, and Activi...
WARNING: THE LC50 VALUES HEREUNDER ARE ESTIMATED ON THE BASIS OF A 4-HOUR EXPOSURE. Acute oral toxicity (LD50): 83 mg/kg [Mouse]. Acute toxicity of the vapor (LC50): 570 ppm 4 hour(s) [Rat]. Chronic Effects on Humans:The substance is toxic to lungs, liver, mucous membranes. ...
Because of its high toxicity, hydrazine is hazardous not only to humans and other animal life, but also to the environment (soil and vegetation). The health effects of the hydrazine family of compounds are still being actively investigated and are not yet fully understood. Consequently, the ...
May alter genetic material Accute Health Effects: Hydrazine is listed by NTP (sufficient evidence of carcinogenicity from studies in experimental animals), IARC (Possibly Carcinogenic to Humans: Limited evidence in humans in the absence of sufficient evidence in experimental animals.) and regulated as ...
Although the effects of neonatal hyperthyroidism on the levels of 4-hydroxy-3-methoxyphenylglycol, an important metabolite of NE, were not examined in this study, unaltered steady-state levels of brain NE seen in these rats appear to be due to increased rate of synthesis and release of this ...
Piperazine is useful only on Ascaris and has mild side effects. Bephenium is a nicotinic agonist and is only moderately effective on hookworm. The avermectins are by far the most powerful antiparasitics known; on Onchocerus volvulus 50 ug/kg is enough to cause dramatic reduction of microf...