Drug toxicity Immune complex disease MHCLong‐term treatment with hydralazine is sometimes associated with deposition of immune complexes and development of systemic lupus erythematosus (SLE) as an adverse side‐effect. Hydralazine inhibits the covalent binding reaction of the complement protein C4. We ...
This fixed-combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not st...
Drug Classes:antihypertensive, vasodilator Availability:prescription only, generic available How is it used?liquid that is injected into a blood vessel or muscle, tablet that is swallowed Uses Side Effects Warnings & Precautions Interactions Overdose/Missed Dose ...
There are no data on BiDil use in pregnant women, and insufficient data on its components (hydralazine and isosorbide dinitrate) to assess a drug-associated risk of major birth defects or miscarriage with first trimester use. Available published data on hydralazine use in pregnancy during the seco...
we report that the FDA approved drug hydralazine is a bona fide activator of the NRF2/SKN-1 signaling pathway. We demonstrate that hydralazine extends healthy lifespan (~25%) in wild type and tauopathy modelC. elegansat least as effectively as other anti-aging compounds, such as curcumin and...
as a new drug delivery carrier, HYD-NDs have great biosafety, tumor targeting, and ultrasound imaging performance. According to the results, the combined therapy reasonably regulated the process of tumor cell pyroptosis, which offered a new strategy for optimizing the therapy of GSDME-silenced solid...
Therapeutic activation of mitochondrial function has been suggested as an effective strategy to combat aging. Hydralazine is an FDA-approved drug used in the treatment of hypertension, heart failure and cancer. Hydralazine has been recently shown to promote lifespan inC. elegans, rotifer and yeast th...
Tetrazolo [5,1-α] phthalazine (Tetra-P) was detected in the urine of a patient on hydralazine treatment. Tetra-P is a new type of monoamine oxidase (MAO) ... Noda,Minemoto,Zaitsu,... - 《Chemical & Pharmaceutical Bulletin》 被引量: 0发表: 1981年 Mechanisms of drug-induced lupus....
The objective of this study was to investigate the potential effects of hydralazine (Hyd, a hypertension treatment drug) on the development process of AD and its mechanisms. We treated 6-month-old male APP/PS1 mice with Hyd for 5 weeks, measured changes in behavior and pathological status, ...
Flow cytometric analysis of adriamycin-treated cells for 1 h show that wild-type MCF-7 cells retain the majority of adriamycin inside the cell (M1); however, MCF-7/Adr cells have essentially no drug accumulation, indicative of the presence of a functional mdr1 protein, and d: MCF-7/adr ...