Hyaluronic acid (HA; Sigma Alrich, USA; molecular weight 8–15 kDa) was attached to the cubosomes by click chemistry coupling using DBCO-PEG4-amine (Kerafast, Inc. Boston, USA). Briefly, 2 mL of (5 mg/mL) HA in
Specifically, a myriad of different synthetic routes to obtain polymerizable hyaluronic acid and chondroitin sulfate derivatives are described. The effects of important parameters such as degree of (meth)acrylation and molecular weight of the synthesized polymers on the formed hydrogels are discussed and...
Article https://doi.org/10.1038/s41467-023-40270-5 Hyaluronic acid-bilirubin nanomedicine- based combination chemoimmunotherapy Received: 1 May 2022 Accepted: 20 July 2023 Check for updates Yonghyun Lee 1,2,3,4 , Jongyoon Shinn1,2, Cheng Xu3,4, Hannah E. Dobson 3,4, Nouri Neamati5 & ...
Topical hyaluronic acid in a serum formulation can increase skin hydration by 55%, as measured by corneometry. Topical hyaluronic acid skin hydration is visualized as improved skin plumping, smoothness, and overall skin appearance. Topical hyaluronic acid possesses an excellent skin tolerability profile...
we report the development of hyaluronic acid–bilirubin nanomedicine (HABN) that accumulates in inflamed colonic epithelium and restores the epithelium barriers in a murine model of acute colitis. Surprisingly, HABN also modulates the gut microbiota, increasing the overall richness and diversity and mar...
Article https://doi.org/10.1038/s41467-023-40270-5 Hyaluronic acid-bilirubin nanomedicine- based combination chemoimmunotherapy Received: 1 May 2022 Accepted: 20 July 2023 Check for updates Yonghyun Lee 1,2,3,4 , Jongyoon Shinn1,2, Cheng Xu3,4, Hannah E. Dobson 3,4, Nouri Neamati5 & ...
Collectively, these findings underscore the immense potential of this versatile hydrogel formulation in expediting diabetic chronic wound healing processes. 4. Methods and materials 4.1. Materials Hyaluronic acid (MW 40 kDa–140 kDa) and dopamine hydrochloride were purchased from Yuanye Bio (Shanghai ...
Breast cancer Cancer stem cells CD44 Hyaluronic acid Nanoparticle Naproxen 1. Introduction Breast cancer is the most frequently diagnosed cancer among women, accounting for 24.5% of all new cancer cases in 2020 worldwide. Importantly, for the first time, female breast cancer has become the most co...
Hyaluronic acid (HA) and compositions comprising HA have been known for a long time. HA has been combined with various other compounds and applied in a number of medical applications. In gel formulations, such applications include treatment of joint problems, and particularly for knee joint problem...
and by its passage through the nasolacrimal duct. Polymers such as hyaluronic acid, polyacrylates, chitosan, cellulose derivatives, pectins, alginate, polyvinyl alcohol, polyvinylpyrrolidone, etc. are usually employed to control viscosity and mucoadhesion. In the design of an ophthalmic formulation, ...