The elimination half-life (t1/2β) of hyaluronic acid has been calculated as 2.5 to 5.5 minutes in human plasma. As demonstrated in rabbits, the t1/2β in the eye is correlated with the volume of the formulation, but its relationship to molecular weight is equivocal. The contribution of ...
(9):17-22. Jarvis LM. "Behind The Surge: A swell in FDA approvals has many wondering whether the drug industry has finally gotten better at R&D." Chemical & Engineering News 2011, 89(31):23-25. Jaser W, Severin GF, J�tting U, Hyaluronic Acid Eye Cream J�ttner I, Schramm K...
Here, we developed a PHI-Hyaluronic acid (HA) composite mEXO (PHI-HA-mEXO) drug delivery system, in which DSPE-PEG2000-HA was conjugated to the surface of mEXO to prepare HA-mEXO, and PHI was encapsulated into HA-mEXO to form PHI-HA-mEXO. As a specific receptor for HA, CD44 ...
However, in this study, we did not explore the exact local concentration of PFD, nor did we specifically distinguish the effects of local application of hyaluronic acid and PFD, which still needs further study. After treatment with a special medium, the fibroblasts were observed to shrink to an...
Hyaluronic acid Keratinocyte growth factor 2 Safety Osteoarthritis 1. Introduction Osteoarthritis (OA) is one of the most commonchronic diseases, which causes degenerative changes in articular cartilage and subchondral bones[1],[2]. In recent years, with an aging and increasingly obese population, OA...
For the wound healing studies with dogs and horses, the film formulation was chosen for its advantages and the length of time between scheduled treatments. The dogs and horses both had slower rates of wound healing than the rats. As the rate of wound healing will depend on not only the ...
Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer. Small 2014, 10, 524−535. (28) Lee, H.; Choi, S. H.; Park, T. G. Direct Visualization of Hyaluronic Acid Polymer Chain by Self-Assembled One-Dimensional Array of...
asanano-sizeddrugformulationforchemotherapy. ©2014ElsevierLtd.Allrightsreserved. 1.Introduction Vorinostat(VRS),ahistonedeacetylaseinhibitor,hasbeen approvedbytheFDAfortreatmentofcutaneousT-celllymphoma (CTCL)(Caietal.,2010;Choo,Ho&Lin,2008).Inclinicaltrials,it ...
In this study, to deliver proteins to cancer cells, we prepared conjugates consisting of bovine serum albumin (BSA) and hyaluronic acid (HA). These conjugates contained multiple BSA and HA molecules and adopted a highly condensed structure by crosslinking through BSA. When the interaction between ...
Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention Biomaterials, 35 (12) (2014), pp. 3903-3917 View PDFView articleView in ScopusGoogle Scholar [24] Y. Deng, et al. Injectable in situ cross-linking chitosan-hyaluronic ...