Hyaluronic acid derivatives injection Hyaluronic acid(HA) is aglycosaminoglycanmolecule and a natural major component ofsynovial fluidand it is also present inhyaline cartilage[13,34,35]. The amount ofHAapproximates 3–4ml in each knee and acts as a jointlubricantandshockabsorber, improving joint ...
After 4 weeks post-injection, the knee joint samples were collected for histological analysis. 2.12. Histological analysis The in vitro hydrogel samples were collected after 3 weeks of culture, and mice with intra-articular injection were sacrificed 4 weeks post-injection. All samples were fixed ...
and no other abnormalities were observed at the injection site during the experiment. In addition, IHC staining of the knee joints showed that the expression of IL-1β and IL-6 was not found in the 15% (w/w) PHA group or saline group (Fig. 4E,...
Therapeutic effect of intra-articular injection of high molecular weight hyaluronic acid on osteoarthritis of the knee. Int. J. Clin. Pharmacol. Ther. Toxicol. 1982, 20, 501–507. [PubMed] 25. Leardini, G.; Perbellini, A.; Franceschini, M.; Mattara, L. Intra-articular injections of ...
This study concerns grafting hyaluronic acid (HA) onto PLGA nanoparticles to improve the tissue specificity of drug delivery. Due to its endogenicity in synovial fluid, HA is known to reduce frictional force within the knee joint by acting as a viscoelastic lubricant. It has the ability to bind...
Hyaluronic acid(HA)/chitosan-poly(dioxanone)(CH-PDO) complex nanoparticles (NPs) with optimized composition and high encapsulation efficiency were employed as a vehicle for loading bone morphogenic protein-7 (BMP-7). BMP-7-loaded HA/CH-PDO NPs were incorporated into ALG-POL/SF hydrogel for ...
In antigen-induced arthritis rats, the intra-articular injection of the HA–MTX conjugate containing the Asn-Phe-Phe linker showed significant reduction of knee swelling. In contrast, intra-articularly injected free MTX and the mixture of HA and MTX showed little or no effect. Of note, the ...
International Journal of Molecular Sciences Article Dual Function of Glucosamine in Gelatin/Hyaluronic Acid Cryogel to Modulate Scaffold Mechanical Properties and to Maintain Chondrogenic Phenotype for Cartilage Tissue Engineering Chih-Hao Chen 1,2,†, Chang-Yi Kuo 1,†, Yan-Jie Wang 1 and Jyh-...
pharmaceuticals Article A Safe-by-Design Approach for the Synthesis of a Novel Cross-Linked Hyaluronic Acid with Improved Biological and Physical Properties Sabrina Sciabica 1,†, Riccardo Barbari 1,† , Riccardo Fontana 2 , Giovanni Tafuro 3, Alessandra Semenzato 4 , Daniela Traini 5,6 , ...