Williams, Frances MKSpector, Tim DPubMedNature Clinical Practice RheumatologyWilliams FM, Spector TD. Are intra-articular injections of hylan more effective than injections of hyaluronic acid for knee osteoarthritis? Nat Clin Pract Rheumatol. 2008;4(8):400–1....
Briefly, sodium hyaluronate (Lifecore Biomedical) was dissolved into 0.2 M 2-(N-morpholino) ethanesulfonic acid (MES) buffered saline (Thermo Fisher Scientific) to make 1% (w/v) HA solution. While stirring, N-hydroxysulfosuccinimide (sulfo-NHS; Sigma-Aldrich) and N-(3-dimethylaminopropyl)-N-...
Intra-articular injections of hyaluronic acid in the treatment of painful shoulder. Clin. Ther. 1988, 10, 521–526. [PubMed] 26. Dougados, M.; Nguyen, M.; Listrat, V.; Amor, B. High molecular weight sodium hyaluronate (hyalectin) in osteoarthritis of the knee: A 1year placebo-...
Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl and hydroxyl groups. Moreover, HA serves as a natural ...
Hyaluronic acid (HA) has been conjugated to trypsin and ribonuclease A (RNase A) as proof of concept of PUMPT. The model proteins were randomly modified exploiting the free amino groups present on the protein surface and activating the carboxyl groups of the polymer via NHS/DCC (figure 11, ...
(NPs) surfaces decorated with hyaluronic acid (HA) to enhance targeted drug specificity to the osteoarthritic knee joint. HA was selected since it binds to specific receptors expressed in many cells, such as the cluster determinant 44 (CD44), a major receptor of chondrocytes, and because of ...
pharmaceuticals Article A Safe-by-Design Approach for the Synthesis of a Novel Cross-Linked Hyaluronic Acid with Improved Biological and Physical Properties Sabrina Sciabica 1,†, Riccardo Barbari 1,† , Riccardo Fontana 2 , Giovanni Tafuro 3, Alessandra Semenzato 4 , Daniela Traini 5,6 , ...