This finding showed that the prodrug effectively prolonged the residence time of CPT in the cells. Figure 4. The chemical structure of the hyaluronan-CPT conjugate. (A) An amino acid-CPT derivative is linked to an HA-ADH derivative; (B) CPT is directly conjugated to carboxylic groups of HA...
Polymers 2014, 6, 346-369; doi:10.3390/polym6020346 Review OPEN ACCESS polymers ISSN 2073-4360 www.mdpi.com/journal/polymers Hyaluronic Acid Bioconjugates for the Delivery of Bioactive Molecules Anna Mero 1,* and Monica Campisi 2 1 Department of Pharmaceutical and Pharmacological Sciences, University...